ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Correlation Transfer by Layer 5 Cortical Neurons Under Recreated Synaptic Inputs
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons.PLoS computational biology · 2022Article
- VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli.eLife · 2020Article
- Enhanced dynamic functional connectivity (whole-brain chronnectome) in chess experts.Scientific reports · 2020Article
- Homogeneous and Narrow Bandwidth of Spike Initiation in Rat L1 Cortical Interneurons.Frontiers in cellular neuroscience · 2020Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Correlated electrical activity in neurons is a prominent characteristic of cortical microcircuits. Despite a growing amount of evidence concerning both spike-count and subthreshold membrane potential pairwise correlations, little is known about how different types of cortical neurons convert correlated inputs into correlated outputs. We studied pyramidal neurons and two classes of GABAergic interneurons of layer 5 in neocortical brain slices obtained from rats of both sexes, and we stimulated them with biophysically realistic correlated inputs, generated using dynamic clamp. We found that the physiological differences between cell types manifested unique features in their capacity to transfer correlated inputs. We used linear response theory and computational modeling to gain clear insights into how cellular properties determine both the gain and timescale of correlation transfer, thus tying single-cell features with network interactions. Our results provide further ground for the functionally distinct roles played by various types of neuronal cells in the cortical microcircuit.
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