Evidence map›Paper›PMID 31345995›Full record

ArticleGenetics2019

Spatial Regulation of Polo-Like Kinase Activity During

Baptiste Roelens, Consuelo Barroso, Alex Montoya, Pedro Cutillas, Weibin Zhang, Alexander Woglar, Chloe Girard, Enrique Martinez-Perez, Anne M Villeneuve

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Baptiste RoelensDepartments of Developmental Biology and Genetics, Stanford University School of Medicine, California 94305.ORCID 0000-0003-0118-0229
Consuelo BarrosoMRC London Institute of Medical Sciences, Imperial College London, W12 0NN, UK.
Alex MontoyaMRC London Institute of Medical Sciences, Imperial College London, W12 0NN, UK.
Pedro CutillasMRC London Institute of Medical Sciences, Imperial College London, W12 0NN, UK.
Weibin ZhangDepartments of Developmental Biology and Genetics, Stanford University School of Medicine, California 94305.
Alexander WoglarDepartments of Developmental Biology and Genetics, Stanford University School of Medicine, California 94305.
Chloe GirardDepartments of Developmental Biology and Genetics, Stanford University School of Medicine, California 94305.ORCID 0000-0002-1459-6226
Enrique Martinez-PerezMRC London Institute of Medical Sciences, Imperial College London, W12 0NN, UK.
Anne M VilleneuveDepartments of Developmental Biology and Genetics, Stanford University School of Medicine, California 94305 annev@stanford.edu.ORCID 0000-0001-5193-2076
Stanford University · USImperial College London · GBMRC London Institute of Medical Sciences · GB

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Meiotic Chromosome Inheritance in C. elegansR35GM126964 · NIGMS · STANFORD UNIVERSITY · PI ANNE M VILLENEUVE · 2018 to 2026
$6.2M
MEIOTIC CHROMOSOME SEGREGATION IN C. ELEGANSR01GM053804 · NIGMS · STANFORD UNIVERSITY · PI VILLENEUVE, ANNE M · 1996 to 2017
$5.7M
Medical Research Council MC-A652-5PY60Medical Research Council MC_U120097113NIGMS NIH HHS R01 GM053804NIGMS NIH HHS R35 GM126964NIH HHS P40 OD010440
6 · The paper itself

Abstract

Proper partitioning of homologous chromosomes during meiosis relies on the coordinated execution of multiple interconnected events: Homologs must locate, recognize, and align with their correct pairing partners. Further, homolog pairing must be coupled to assembly of the synaptonemal complex (SC), a meiosis-specific tripartite structure that maintains stable associations between the axes of aligned homologs and regulates formation of crossovers between their DNA molecules to create linkages that enable their segregation. Here, we identify HAL-3 (Homolog Alignment 3) as an important player in coordinating these key events during

Indexed as

MeiosisAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell Cycle ProteinsMutationNuclear ProteinsPolo-Like Kinase 1Polo-like KinasesProtein BindingProtein Serine-Threonine KinasesSynaptonemal ComplexCaenorhabditis elegans ProteinsCell Cycle ProteinsHAL-2 protein, C eleganshal-3 protein, C elegansNuclear Proteinsplk-1 protein, C elegansPolo-Like Kinase 1polo-like kinase 2, C elegansPolo-like KinasesProtein Serine-Threonine KinasesC. eleganscell cyclemeiosisnucleoplasmPolo-like kinase

Identifiers

PMID31345995
PMCPMC6727811
OpenAlexW2963886540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.