Evidence map›Paper›PMID 31345970›Full record

Observational studyBMJ open2019

Potential missed opportunities to prevent ischaemic stroke: prospective multicentre cohort study of atrial fibrillation-associated ischaemic stroke and TIA.

Duncan Wilson, Gareth Ambler, Clare Shakeshaft, Gargi Banerjee, Andreas Charidimou, David Seiffge, Mark White, Hannah Cohen, Tarek Yousry, Al-Shahi Salman R and 6 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02513316 (Microbleeds and Genetic Risk Factors to Predict the Risk of Intracranial Haemorrhage in Patients Treated With Anticoagulation Following Cardioembolic Stroke Due to Atrial Fibrillation), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02513316 completednot on this map

Microbleeds and Genetic Risk Factors to Predict the Risk of Intracranial Haemorrhage in Patients Treated With Anticoagulation Following Cardioembolic Stroke Due to Atrial Fibrillation

TypeobservationalSponsorUniversity College, LondonRan2011 to 2017Enrolled2,490ConditionsStroke, Atrial Fibrillation (AF), Intracerebral Haemorrhage (ICH)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. [Prognostic analysis of anticoagulation therapy in elderly patients with cardioembolic stroke].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Duncan WilsonNew Zealand Brain Research Institute, Christchuch, New Zealand.
Gareth AmblerDepartment of Statistical science, University College London, London, UK.
Clare ShakeshaftBrain Repair and Rehabilitation, Institute of Neurology, UCL, London, UK.
Gargi BanerjeeBrain Repair and Rehabilitation, Institute of Neurology, UCL, London, UK.
Andreas CharidimouStroke Research Group, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK.ORCID 0000-0001-5891-337X
David SeiffgeBrain Repair and Rehabilitation, Institute of Neurology, UCL, London, UK.
Mark WhiteBrain Repair and Rehabilitation, Institute of Neurology, UCL, London, UK.
Hannah CohenHaemostasis Research Unit, Department of Haematology, University College London, London, UK.
Tarek YousryLysholm Department of Neuroradiology, University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery, London, UK.
Al-Shahi Salman RCentre for clinical brain sciences, University of Edinburgh, Edinburgh, UK.
Gregory Y H LipInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
Keith MuirUniversity of Glasgow, Glasgow, UK.
Martin M BrownNeurology, UCL, London, UK.
H R JägerStroke Research Group, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK.
David J WerringDepartment of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK.
CROMIS-2 collaborators
University College London · GBHarvard University · USNational Hospital for Neurology and Neurosurgery · GBNew Zealand Brain Research Institute · NZUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Birmingham · GBUniversity of Edinburgh · GBUniversity of Glasgow · GB

Funding

British Heart FoundationMedical Research Council G1002605Medical Research Council MR/M009106/1
6 · The paper itself

Abstract

objectiveWe report on: (1) the proportion of patients with known atrial fibrillation (AF); and (2) demographic, clinical or radiological differences between patients with known AF (and not treated) and patients with newly diagnosed AF, in a cohort of patients who presented with ischaemic stroke or transient ischaemic attack (TIA) not previously treated with anticoagulation.

designWe reviewed cross-sectional baseline demographic and clinical data from a prospective observational cohort study, (CROMIS-2).

settingPatients were recruited from 79 hospital stroke centres throughout the UK and one centre in the Netherlands.

participantsPatients were eligible if they were adults who presented with ischaemic stroke or TIA and AF and had not been previously treated with oral anticoagulation.

main outcome measuresProportion of patients with known AF before index ischaemic stroke or TIA from a cohort of patients who have not been previously treated with oral anticoagulation. Secondary analysis includes the comparison of CHA

resultsOf 1470 patients included in the analysis (mean age 76 years (SD 10)), 622 (42%) were female; 999 (68%) patients had newly diagnosed AF and 471 (32%) patients had known AF. Of the 471 patients with known AF, 68% had a strong indication for anticoagulation and 89% should have been considered for anticoagulation based upon CHA

conclusionsAbout 1/3 of patients who present with stroke and have AF who have not been treated with oral anticoagulation have previously known AF. Of these patients, at least 68% were not adequately treated with oral anticoagulation. TRIAL REGISTRATION NUMBER: NCT02513316.

Indexed as

AgedAged, 80 and overAtrial FibrillationComorbidityCross-Sectional StudiesFactor Xa InhibitorsFemaleHumansIschemic Attack, TransientMaleProspective StudiesRisk AdjustmentRisk AssessmentStrokeFactor Xa Inhibitorsanticoagulationatrial fibrillationstroke

Identifiers

PMID31345970
PMCPMC6661679
OpenAlexW2963626706

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.