Evidence map›Paper›PMID 31345941›Full record

ArticleAJNR. American journal of neuroradiology2019

Leukoaraiosis May Confound the Interpretation of CT Perfusion in Patients Treated with Mechanical Thrombectomy for Acute Ischemic Stroke.

S Rudilosso, C Laredo, C Vivancos, X Urra, L Llull, A Renú, V Obach, Y Zhao, J L Moreno, A Lopez-Rueda and 2 more

Open access · bronzeAbstract read

In one paragraph

Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

1.1field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

Perfusion Status in Lacunar Stroke: A Pathophysiological Issue.Diagnostics (Basel, Switzerland) · 2023
Review
CT Perfusion in Lacunar Stroke: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023
Review
Spatial accuracy of computed tomography perfusion to estimate the follow-up infarct on diffusion-weighted imaging after successful mechanical thrombectomy.BMC neurology · 2023
Article
Mediating roles of leukoaraiosis and infarcts in the effects of unilateral carotid artery stenosis on cognition.Frontiers in aging neuroscience · 2022
Article
Severe Cerebral Small Vessel Disease Burden Is Associated With Poor Outcomes After Endovascular Thrombectomy in Acute Ischemic Stroke With Large Vessel Occlusion.Cureus · 2021
Article
White matter burden does not influence the outcome of mechanical thrombectomy.Journal of neurology · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

S RudilossoFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.ORCID 0000-0002-8775-6884

C LaredoFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.ORCID 0000-0002-4626-6360

C VivancosNeurosurgery Service (C.V.), Universitary Hospital La Paz, Madrid, Spain.ORCID 0000-0002-6230-9287

X UrraFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.ORCID 0000-0002-4763-5252

L LlullFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.ORCID 0000-0001-6897-2277

A RenúFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.ORCID 0000-0001-9169-6856

V ObachFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.ORCID 0000-0002-0518-1053

Y ZhaoFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.ORCID 0000-0002-6981-1536

J L MorenoDepartment of Radiology (J.L.M., A.L.-R.), Hospital Clínic, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-0750-2797

A Lopez-RuedaDepartment of Radiology (J.L.M., A.L.-R.), Hospital Clínic, University of Barcelona, Barcelona, Spain.ORCID 0000-0001-7914-9948

S AmaroFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain achamorro@clinic.ub.es samaro@clinic.cat.ORCID 0000-0001-6838-6390

Á ChamorroFrom the Department of Neuroscience (S.R., C.L., X.U., L.L., A.R., V.O., Y.Z., S.A., Á.C.)., Comprehensive Stroke Center, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain achamorro@clinic.ub.es samaro@clinic.cat.ORCID 0000-0003-0493-5340

Biomedical Research Institute · USHospital Clínic de Barcelona · ESBarcelona Graduate School of Mathematics · ESHospital Universitario La Paz · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeLeukoaraiosis frequently coexists in patients with acute stroke. We studied whether leukoaraiosis could confound the interpretation of CTP findings in patients treated with mechanical thrombectomy. MATERIALS AND

methodsWe analyzed 236 patients with stroke treated with mechanical thrombectomy and studied with CTP, of whom 127 (53.8%) achieved complete reperfusion. Periventricular white matter hyperintensities on MR imaging and hypodensities on NCCT were assessed through the Fazekas score. CTP-predicted nonviable tissue was defined as relative CBF <30%, and final infarct volume was quantified in DWI. We estimated mean MTT, CBV, and CBF in the asymptomatic hemisphere. In patients achieving complete reperfusion, we assessed the accuracy of nonviable tissue to predict final infarct volume using the intraclass correlation coefficient across periventricular hyperintensity/hypodensity Fazekas scores and variable relative CBF cutoffs.

resultsMTT was longer (Spearman ρ = 0.279,

conclusionsIn patients with stroke, the presence of leukoaraiosis confounds the interpretation of CTP despite proper adjustment of CBF thresholds.

Indexed as

AgedAged, 80 and overFemaleHumansLeukoaraiosisMaleMiddle AgedNeuroimagingPerfusion ImagingReperfusionReproducibility of ResultsRetrospective StudiesStrokeThrombectomyTomography, X-Ray Computed

Identifiers

PMID31345941

DOI10.3174/ajnr.A6139

PMCPMC7048478

OpenAlexW2964142051

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.