Evidence map›Paper›PMID 31345938›Full record

ArticleGenome research2019

Whole-genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes.

Eric R Lucas, Alistair Miles, Nicholas J Harding, Chris S Clarkson, Mara K N Lawniczak, Dominic P Kwiatkowski, David Weetman, Martin J Donnelly, Anopheles gambiae 1000 Genomes Consortium

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.

  1. Pooled it
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  13. Complex Roles of Insect Cytochrome P450s in Chemical Adaptation.International journal of biological sciences · 2026
    Review
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  19. An atlas of positive selection in the genomes of major malaria vectors.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Eric R LucasLiverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.ORCID 0000-0003-3892-1668
Alistair MilesWellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom.
Nicholas J HardingBig Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, Oxford OX3 7LF, United Kingdom.
Chris S ClarksonWellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom.
Mara K N LawniczakWellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom.
Dominic P KwiatkowskiWellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom.ORCID 0000-0002-5023-0176
David WeetmanLiverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
Martin J DonnellyLiverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
Anopheles gambiae 1000 Genomes Consortium
Wellcome Sanger Institute · GBLiverpool School of Tropical Medicine · GBUniversity of Oxford · GB

Funding

Genome-based diagnostics for monitoring and evaluation of insecticide resistance in Anopheles gambiaeR01AI116811 · NIAID · TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE · PI Martin James Donnelly · 2016 to 2026
$4.6M
Medical Research Council MR/M006212/1Medical Research Council MR/P02520X/1NIAID NIH HHS R01 AI116811Wellcome Trust 090532/Z/09/ZWellcome Trust 090770/Z/09/ZWellcome Trust 098051Wellcome Trust 204911/Z/16/Z
6 · The paper itself

Abstract

Polymorphisms in genetic copy number can influence gene expression, coding sequence, and zygosity, making them powerful actors in the evolutionary process. Copy number variants (CNVs) are however understudied, being more difficult to detect than single-nucleotide polymorphisms. We take advantage of the intense selective pressures on the major malaria vector

Indexed as

DNA Copy Number VariationsGenome, InsectAnimalsAnophelesBiological EvolutionChromosome MappingCytochrome P-450 Enzyme SystemGene DosageGenetic LociHaplotypesHomozygoteHumansInsecticide ResistanceInsecticidesInsect ProteinsMalariaCytochrome P-450 Enzyme SystemInsecticidesInsect ProteinsPyrethrins

Identifiers

PMID31345938
PMCPMC6673711
OpenAlexW2963088478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.