ArticleOral oncology2019
Incidence and outcomes of radiation-induced late cranial neuropathy in 10-year survivors of head and neck cancer.
Article in Oral oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Longitudinal Patterns of Radiation-Associated Dysphagia in Patients With Head and Neck Cancer: A Systematic Review.Head & neck · 2026Pooled it
- Trial
- Establishment and Validation of a Predictive Model for Radiation-Associated Aspiration Pneumonia in Patients with Radiation-Induced Dysphagia after Nasopharyngeal Carcinoma.Behavioural neurology · 2022Trial
- Cancer pain.Nature reviews. Disease primers · 2026Review
- MDASI-HN Symptom Profiling for Early-Risk Stratification of Hypoglossal Neuropathy in Survivors of Oropharyngeal Cancer.JAMA otolaryngology-- head & neck surgery · 2026Article
- Bilateral vocal fold immobility following head and neck radiotherapy: an institutional review.The Journal of laryngology and otology · 2026Review
- Deferoxamine Improves Radiation-Induced Peripheral Neuropathy.Journal of cellular and molecular medicine · 2026Article
- Long-term outcomes among individuals living with and beyond head and neck cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Article
- Long-Term Feeding Tube Use in Head and Neck Cancer Survivors-An Analysis of Patient- and Treatment-Related Factors.International journal of radiation oncology, biology, physics · 2025Article
- Late radiation-associated dysphagia following treatment for head and neck cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Revealing the Enigma: A Deep Dive Into Submandibular Adenoid Cystic Carcinoma and Its Management.Cureus · 2024Article
- Assessment of medical students' knowledge regarding radiation associated risk and its protection: finding from a cross-sectional study.Irish journal of medical science · 2024Article
- Intensity-modulated radiotherapy with planned Gamma Knife radiosurgery boost for head and neck cancer with extensive disease in proximity to critical structures.Head & neck · 2022Article
- State of Rehabilitation Research in the Head and Neck Cancer Population: Functional Impact vs. Impairment-Focused Outcomes.Current oncology reports · 2022Review
- Review
- Human organ donor-derived vagus nerve biopsies allow for well-preserved ultrastructure and high-resolution mapping of myelinated and unmyelinated fibers.Scientific reports · 2021Article
- Article
- Article
- Clinical Review of Proton Therapy in the Treatment of Unilateral Head and Neck Cancers.International journal of particle therapy · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo characterize the late cranial neuropathy among 10-year survivors of head and neck cancer treatment. MATERIALS AND
methodsWe retrospectively evaluated patients treated with curative-intent radiation for HNC between 1990 and 2005 at a single institution with systematic multidisciplinary follow-up ≥ 10 years. New findings of CNP were considered radiation-induced when examination, imaging and/or biopsy did not demonstrate a structural or malignant cause. Cox proportional hazards modeling was used for univariable analysis (UVA) and multivariable analysis (MVA) for time to CNP after completion of radiation.
resultsWe identified 112 patients with no evidence of disease and follow-up ≥ 10 years (median 12.2). Sixteen (14%) patients developed at least one CNP. The median time to CNP was 7.7 years (range 0.6-10.6 years). Most common was CN XII deficit in eight patients (7%), followed by CN X deficit in seven patients (6%). Others included CN V deficit in three, and CN XI deficit in two. Eight of the thirteen patients with a CN X and/or CN XII deficit required a permanent gastrostomy tube. On UVA, site of primary disease, post-radiation neck dissection, chemotherapy, and radiation dose were significantly associated with increased risk of CNP.
conclusionIatrogenic CNP may develop years after head and neck cancer treatment and often leads to swallowing dysfunction. Long-term follow up is essential for these patients receiving head and neck radiation.
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Registered trials
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