Evidence map›Paper›PMID 31345376›Full record

ArticleOral oncology2019

Role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery: A subgroup analysis of the meta-analysis of chemotherapy in head and neck cancer.

Etienne Dauzier, Benjamin Lacas, Pierre Blanchard, Quynh-Thu Le, Christian Simon, Gregory Wolf, François Janot, Masatoshi Horiuchi, Jeffrey S Tobias, James Moon and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Comparative efficacy and safety of radiotherapy/cetuximabTherapeutic advances in medical oncology · 2020
    Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Etienne DauzierMeta-Analysis Unit, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Benjamin LacasMeta-Analysis Unit, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Pierre BlanchardMeta-Analysis Unit, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France; Department of Radiation Therapy, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
Quynh-Thu LeDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Christian SimonDepartment of Otolaryngology and Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Gregory WolfDepartment of Otolaryngology, University of Michigan, Ann Arbor, USA.
François JanotDépartement de Cancérologie Cervico-faciale, Gustave Roussy Cancer Campus, Université Paris Sud, Villejuif, France.
Masatoshi HoriuchiDepartment of Otolaryngology, Tokai University School of Medicine, Kanagawa, Japan.
Jeffrey S TobiasDepartment of Radiotherapy, University College London Hospital, London, UK.
James MoonSWOG Statistical Center, Seattle, WA, USA.
John SimesNHMRC Clinical Trials Center, Camperdown, Australia.
Vinay DeshmaneSurgical Oncology & Breast Diseases, P.D. Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Jean-Jacques MazeronDépartement de radiothérapie, hôpital Pitié-Salpêtrière, Paris, France.
Samir MehtaDepartment of Surgery, Sarla Hospital, Mumbai, India.
Branko ZaktonikDepartment of Medical Oncology, Institute of Oncology, Ljubljana, Slovenia.
Minoru TamuraDept. of Dentistry and Oral Surgery, Shinshu University School of Medicine, Japan.
Elizabeth MoyalDépartement de radiothérapie, IUCT Oncopole - CLCC Institut Claudius Regaud, Toulouse, France.
Lisa LicitraDepartment of Medical Oncology 3, Fondazione IRCCS-Istituto Nazionale dei Tumori, Milano and University of Milan, Italy.
Catherine FortpiedEORTC Headquarters, Brussels, Belgium.
Bruce G HafftyDept. of Therapeutic Radiology, Rutgers Robert Wood Johnson and NJ Medical School, NJ, USA.
Maria Grazia GhiOncology Unit 2, Veneto Oncology Institute-IRCCS, Padua, Italy.
Vincent GregoireRadiation Oncology Department, Centre Léon Bérard, Lyon, France.
Jonathan HarrisNRG Oncology Statistics and Data Management Center, American College of Radiology, Philadelphia, USA.
Jean BourhisDepartment of Radiotherapy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Anne AupérinMeta-Analysis Unit, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France. Electronic address: anne.auperin@gustaveroussy.fr.
Jean-Pierre PignonMeta-Analysis Unit, Service de Biostatistique et d'Epidémiologie, Gustave Roussy Cancer Campus, INSERM U1018, CESP, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.
MACH-NC Collaborative Group

Funding

NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
Statistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI James J. Dignam · 2014 to 2026
$146.4M
NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868
6 · The paper itself

Abstract

objectiveTo evaluate the effect of chemotherapy added to a surgical locoregional treatment (LRT) for patients with locally advanced head and neck squamous cell carcinoma (HNSCC). MATERIALS AND

methodsWe studied the sub-group of trials with surgical LRT included in the meta-analysis on chemotherapy in head and neck cancer (MACH-NC). Data from published and unpublished randomized trials comparing the addition of chemotherapy to LRT in HNSCC patients were sought using electronic database searching for the period 1965-2000, hand searching and by contacting experts in the field. Trials with less than 60 patients, or preoperative radiotherapy or where the type of LRT could not be individually determined were excluded. All individual patient data were checked for internal consistency, compared with published reports, and validated with trialists. Data were pooled using a fixed-effect model. Heterogeneity was assessed using Cochrane test and I

resultsTwenty-four trials were eligible (5000 patients). Chemotherapy improved overall survival (HR = 0.92 [95%CI: 0.85-0.99] p = 0.02). There was a significant interaction between treatment effect and timing of chemotherapy (p = 0.08 at pre-specified threshold of 0.10) with a greater effect for concomitant chemotherapy (HR = 0.79, 95%CI: 0.69-0.92). The benefit of chemotherapy was greater in women (HR

conclusionsThis analysis confirmed the benefit of concomitant chemotherapy added to surgical LRT. The role of induction therapy as yet to be determined as it did not improve OS. Women may benefit more than men from chemotherapy.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansMaleMeta-Analysis as TopicMiddle AgedRandomized Controlled Trials as TopicSquamous Cell Carcinoma of Head and NeckChemotherapyHead and neck cancerIndividual patient dataMeta-analysisRandomized trialSquamous cell carcinomaSurgery

Identifiers

PMID31345376
PMCPMC7029787

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.