Evidence map›Paper›PMID 31345263›Full record

ArticleSystematic reviews2019

A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke.

Kathryn S Hayward, Sharon F Kramer, Vincent Thijs, Julie Ratcliffe, Nick S Ward, Leonid Churilov, Laura Jolliffe, Dale Corbett, Geoffrey Cloud, Tina Kaffenberger and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kathryn S HaywardMelbourne School of Health Sciences, University of Melbourne, Parkville, Melbourne, Australia. kate.hayward@florey.edu.au.ORCID 0000-0001-5240-3264
Sharon F KramerAVERT Early Rehabilitation Research Group, Stroke Theme, Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Australia.
Vincent ThijsStroke Theme, Florey Institute of Neuroscience and Mental Health and Neurology Department, Austin Health, Heidelberg, Melbourne, VIC, Australia.
Julie RatcliffeCollege of Nursing and Health Sciences, Flinders University, Adelaide, Australia.
Nick S WardUCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK.
Leonid ChurilovNHMRC CRE in Stroke Rehabilitation and Brain Recovery, University of Melbourne, Heidelberg, Melbourne, VIC, 3084, Australia.
Laura JolliffeCollege of Science, Health and Engineering, La Trobe University, Bundoora, Melbourne, VIC, Australia.
Dale CorbettDepartment of Cellular and Molecular Medicine, University of Ottawa and Canadian Partnership for Stroke Recovery, Ottawa, Canada.
Geoffrey CloudDepartment of Neurology, Alfred Health, Prahran, Melbourne, VIC, Australia.
Tina KaffenbergerAVERT Early Rehabilitation Research Group, Stroke Theme, Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Australia.
Amy BrodtmannMelbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, Heidelberg, Melbourne, VIC, Australia.
Julie BernhardtAVERT Early Rehabilitation Research Group, Stroke Theme, Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Australia.
Natasha A LanninOccupational Therapy Department, Alfred Health, Prahran, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImproving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to complete three systematic reviews to estimate the (1) association between time to start of UL therapy and motor recovery, (2) relative efficacy of different UL therapy approaches post-stroke and (3) cost-effectiveness of UL therapy interventions.

methodsWe have designed a systematic review protocol to address three systematic review questions that were each registered with PROSPERO. The search will be conducted in MEDLINE, EMBASE, and Cochrane Controlled Register of Trials. We will include randomised controlled trials, non-randomised clinical trials, before-after studies and observational studies of adult stroke survivors with an average stroke onset < 6 months, undergoing hospital-based therapy to improve UL function. Eligible interventions will aim to promote UL functional recovery. Two reviewers will independently screen, select and extract data. Study risk of bias will be appraised using appropriate tools. Clinical measures of motor recovery will be investigated (primary measure Fugl Meyer UL assessment), as well as measures of health-related quality of life (primary measure EQ-5D) and all cost-effectiveness analyses completed. Secondary outcomes include therapy dose (minutes, weeks, repetitions as available) and safety (i.e. adverse events, serious adverse events). A narrative synthesis will describe quality and content of the evidence. If feasible, we will conduct random effects meta-analyses where appropriate. DISCUSSION: We anticipate the findings of this review will increase our understanding of UL therapy and inform the generation of novel, data-driven hypotheses for future UL therapy research post-stroke. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018019367, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018111629, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018111628.

Indexed as

Cost-Benefit AnalysisPhysical Therapy ModalitiesRecovery of FunctionStroke RehabilitationHospitalsHumansQuality of LifeSystematic Reviews as TopicUpper ExtremityProtocolRecoveryRehabilitationStrokeSystematic reviewTherapyUpper limb

Identifiers

PMID31345263
PMCPMC6657039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.