Evidence map›Paper›PMID 31345259›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2019

Impact of metformin on disease control and survival in patients with head and neck cancer: a retrospective cohort study.

Daniel J Lee, Caitlin P McMullen, Andrew Foreman, Shao Hui Huang, Lin Lu, Wei Xu, John R de Almeida, Geoffrey Liu, Scott V Bratman, David P Goldstein

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  11. P-glycoprotein associated with diabetes mellitus and survival of patients with pancreatic cancer: 8-year follow-up.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Daniel J LeeDepartment of Otolaryngology Head and Neck Surgery/Surgical Oncology, University Health Network, Princess Margaret Cancer Center, University of Toronto, 610 University Ave 3-952, Toronto, ON, M4V 2N8, Canada.
Caitlin P McMullenDepartment of Otolaryngology Head and Neck Surgery/Surgical Oncology, University Health Network, Princess Margaret Cancer Center, University of Toronto, 610 University Ave 3-952, Toronto, ON, M4V 2N8, Canada.
Andrew ForemanDepartment of Otolaryngology Head and Neck Surgery/Surgical Oncology, University Health Network, Princess Margaret Cancer Center, University of Toronto, 610 University Ave 3-952, Toronto, ON, M4V 2N8, Canada.
Shao Hui HuangDepartment of Radiation Oncology, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
Lin LuBiostatistics Department, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Wei XuBiostatistics Department, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
John R de AlmeidaDepartment of Otolaryngology Head and Neck Surgery/Surgical Oncology, University Health Network, Princess Margaret Cancer Center, University of Toronto, 610 University Ave 3-952, Toronto, ON, M4V 2N8, Canada.
Geoffrey LiuBiostatistics Department, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Scott V BratmanDepartment of Radiation Oncology, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
David P GoldsteinDepartment of Otolaryngology Head and Neck Surgery/Surgical Oncology, University Health Network, Princess Margaret Cancer Center, University of Toronto, 610 University Ave 3-952, Toronto, ON, M4V 2N8, Canada. david.goldstein@uhn.ca.
Princess Margaret Cancer Centre · CAUniversity Health Network · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA number of in vitro and clinical studies have suggested potential antineoplastic effects of metformin. The impact of this medication on outcomes in head and neck cancer is less clear. Our aim was to determine the effect of metformin on outcomes within our large cohort of head and neck cancer patients with Type II Diabetes (T2DM). STUDY

designRetrospective cohort study.

settingTertiary Cancer Centre. SUBJECTS AND

methodsA retrospective review of individuals with head and neck squamous carcinoma (HNSCC) and T2DM between January 2005 and December 2011 at Princess Margaret Cancer Centre was conducted. Medication history was obtained from surveys at initial presentation and electronic medical record review. Using Cox regression analyses, the association between metformin use and local, regional and distant failures was explored. Subgroup analyses were conducted for oral cavity, oropharynx and larynx.

resultsA total of 329 HNSCC patients with T2DM were identified, including 195 metformin users and 134 non-metformin users. Patients were well-matched in terms of clinical, pathologic, and treatment factors. No difference in local, regional, or distant failure was observed between diabetic metformin users and diabetic non-metformin users for the entire cohort or within subgroup analysis for subsite. No difference between the two groups was observed for overall survival, recurrence-free survival, and disease-specific survival at 5 years.

conclusionNo association between metformin use and oncologic outcomes were observed in this large cohort of HNSCC patients. Multicenter, prospective studies may be needed to verify previous studies identifying a potential anti-neoplastic effect of this medication.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Squamous CellDiabetes Mellitus, Type 2FemaleHead and Neck NeoplasmsHumansHypoglycemic AgentsKaplan-Meier EstimateMaleMetforminMiddle AgedRetrospective StudiesHypoglycemic AgentsMetforminDiabetesHead and neck cancerMetformin

Identifiers

PMID31345259
PMCPMC6659246
OpenAlexW2964014700

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.