Evidence map›Paper›PMID 31345252›Full record

ArticleJournal of cardiothoracic surgery2019

Use of low-dose β

Michihiro Sakai, Satoshi Jujo, Junjiro Kobayashi, Yoshihiko Ohnishi, Masataka Kamei

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiothoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Efficacy of Landiolol for Treatment of Sepsis-Related Tachyarrhythmia: Lost in Translation.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Acute rate control in atrial fibrillation: an urgent need for the clinician.European heart journal supplements : journal of the European Society of Cardiology · 2022
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michihiro SakaiDepartment of Clinical Anesthesiology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Satoshi JujoDepartment of Anesthesiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
Junjiro KobayashiDepartment of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
Yoshihiko OhnishiDepartment of Anesthesiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
Masataka KameiDepartment of Clinical Anesthesiology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. masatakakamei@gmail.com.
National Cerebral and Cardiovascular Center · JPMie University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSinus tachycardia coupled with high-dose catecholamine is common after cardiopulmonary bypass (CPB). The present study assessed the hemodynamic efficacy and safety of combination therapy using low-dose β

methodsThis was a retrospective, single center, self-comparison study at post-anesthesia care unit within a tertiary care center. The study included adults who underwent cardiac surgery with CPB and received landiolol between April 2007 and November 2011. We assessed hemodynamic data prior to and 1 h after initiation of landiolol therapy.

resultsWe evaluated 11 patients who were administered 2.6 ± 1.3 μg/kg/min (mean ± SD) landiolol with sinus tachycardia and received catecholamine therapy after on-pump cardiovascular surgery. Landiolol administration led to a significant reduction in heart rate (HR; 112.4 ± 5.8 vs 126.0 ± 7.6 beats/min, p < 0.001), and a significant increase in stroke volume index (SVI) assessed by pulmonary artery catheterization (22.4 ± 5.4 vs. 18.9 ± 4.2 mL/m

conclusionsLow-dose landiolol therapy may safely decrease HR and improve hemodynamics among patients with sinus tachycardia receiving catecholamine treatment after cardiovascular surgery.

trial registrationThis study is retrospective. Registration number: 11. Duration of registration: April 2007~November 2011.

Indexed as

Cardiac Surgical ProceduresAdrenergic beta-AntagonistsAdultAgedCatecholaminesFemaleHeart RateHemodynamicsHumansJapanMaleMiddle AgedMorpholinesPostoperative ComplicationsRetrospective StudiesTachycardia, SinusAdrenergic beta-AntagonistsCatecholamineslandiololMorpholinesUreaCardiovascular surgeryCatecholamineTachycardia

Identifiers

PMID31345252
PMCPMC6659295
OpenAlexW2963087237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.