SynthesisBMC oral health2019
Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 9 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Platelet-rich fibrin after mandibular third molar extraction: an umbrella review of systematic reviews and meta-analyses.Oral and maxillofacial surgery · 2026Pooled it
- Interventions to minimize periodontal defect distal to second molar after mandibular third molar surgery: an overview of systematic reviews.Oral and maxillofacial surgery · 2025Pooled it
- Efficacy of platelet-rich-fibrin for the treatment of alveolar osteitis: a systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Performance of blood concentrates in controlling inflammatory signs and symptoms after lower third molar extractions: an overview.Acta cirurgica brasileira · 2025Pooled it
- Platelet-rich fibrin application after mandibular third molar extraction: an umbrella review.Clinical oral investigations · 2024Pooled it
- Do blood concentrates influence inflammatory signs and symptoms after mandibular third molar surgery? A systematic review and network meta-analysis of randomized clinical trials.Clinical oral investigations · 2023Pooled it
- Local interventions for the management of alveolar osteitis (dry socket).The Cochrane database of systematic reviews · 2022Pooled it
- Nonpharmacological Complementary Interventions for the Management of Pain after Third Molar Surgery: An Umbrella Review of Current Meta-Analyses.Pain research & management · 2022Pooled it
- Application of platelet-rich fibrin on mandibular third molar extraction: systematic review and Meta-analysis.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Pooled it
- Three-dimensional facial swelling evaluation of pre-operative single-dose of prednisone in third molar surgery: a split-mouth randomized controlled trial.BMC oral health · 2023Trial
- The effect of dental pulp stem cells and L-PRF when placed into the extraction sockets of impacted mandibular third molars on the periodontal status of adjacent second molars: a split-mouth, randomized, controlled clinical trial.Oral and maxillofacial surgery · 2023Trial
- Sutureless socket technique after removal of third molars: a multicentric, open, randomized controlled trial.BMC oral health · 2022Trial
- Postoperative effects of intra-alveolar application of 0.2% chlorhexidine or 1% hyaluronic acid bioadhesive gels after mandibular third molar extraction: a double-blind randomized controlled clinical trial.Clinical oral investigations · 2021Trial
- Randomized controlled trial on the effectiveness of absorbable collagen sponge after extraction of impacted mandibular third molar: split-mouth design.BMC oral health · 2020Trial
- The Effect of Platelet-Rich Fibrin in Preventing Inferior Alveolar Nerve Paresthesia After Mandibular Third Molar Surgery: A Randomized Clinical Trial.European journal of dentistry · 2026Article
- PRF and PRP in Dentistry: An Umbrella Review.Journal of clinical medicine · 2025Review
- Review
- How to explain the beneficial effects of leukocyte- and platelet-rich fibrin.Periodontology 2000 · 2025Review
- Analysis of the oral microbiome composition of healthy individuals and theFrontiers in microbiology · 2025Article
- Postextraction infections, prevention, and treatment.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study investigated and evaluated the efficacy and safety of platelet-rich fibrin (PRF) in patients during bilateral mandibular third molars extraction by systematic review and meta-analysis.
methodsThe PubMed, Embase, and Cochrane library databases were retrieved, and the effect of PRF on the healing process of the alveolar socket after surgical extraction of the mandibular third molars was evaluated by meta-analysis. The postoperative pain, swelling, trismus, osteoblastic activity, and soft tissue healing were assessed, and the incidence of alveolar osteitis, weighted mean difference (WMD)/standard mean difference (SMD), the risk ratio (RR), and the 95% confidence interval (CI) were calculated.
resultsThe current results showed that the local application of PRF during lower third molar extraction prevented postoperative complications. Subsequently, the pain (SMD = - 0.53, 95% CI: - 1.02--0.05, P
conclusionThe current study confirms that PRF only reduces some of the postoperative complications but does not prevent all the postoperative complications. PRF significantly relieved the pain and swelling and reduced the incidence of alveolar osteitis after the extraction of an impacted lower third molar.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.