Evidence map›Paper›PMID 31345131›Full record

ArticleStroke2019

Corticosterone-Mediated Body Weight Loss Is an Important Catabolic Process for Poststroke Immunity and Survival.

Jiwon Yang, Eunhee Kim, Cesar Beltran, Sunghee Cho

Open access · bronzeAbstract read
In one paragraph

Article in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Endothelial cell CD36 mediates stroke-induced brain injury via BBB dysfunction and monocyte infiltration in normal and obese conditions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  6. Article
  7. Article
  8. Remote Postischemic Conditioning Promotes Stroke Recovery by Shifting Circulating Monocytes to CCR2The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jiwon YangFrom the Burke Neurological Institute, White Plains, NY (J.Y., E.K., C.B., S.C.).
Eunhee KimFrom the Burke Neurological Institute, White Plains, NY (J.Y., E.K., C.B., S.C.).
Cesar BeltranFrom the Burke Neurological Institute, White Plains, NY (J.Y., E.K., C.B., S.C.).
Sunghee ChoFrom the Burke Neurological Institute, White Plains, NY (J.Y., E.K., C.B., S.C.).
Beltran (United States) · USJackson Laboratory · US

Funding

The role of CD36 in ischemic inflammation and injuryR01HL082511 · NHLBI · WINIFRED MASTERSON BURKE MED RES INST · PI CHO, SUNGHEE · 2006 to 2014
$4.4M
Role of CD36 in functional recovery in chronic strokeR01NS095359 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI CHO, SUNGHEE · 2015 to 2019
$2.1M
Targeting stroke-induced brain swelling in obese subjects: role of VEGFR01NS103326 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI CHO, SUNGHEE · 2018 to 2022
$2.0M
Impact of BDNF SNP on stroke-induced plasticity and motor functionR01NS077897 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI CHO, SUNGHEE · 2012 to 2016
$2.0M
NHLBI NIH HHS R01 HL082511NINDS NIH HHS R01 NS077897NINDS NIH HHS R01 NS095359NINDS NIH HHS R01 NS103326
6 · The paper itself

Abstract

Background and Purpose- Stroke-induced acute severe body weight (BW) loss is associated with a high rate of mortality during a critical poststroke period. Several interventions to reduce weight loss, however, have not been successful. Currently, the biological significance of this extraordinary catabolic process is not well understood. Spleen-derived monocytes/macrophages (MMs) are the major immune cells recruited to the injured brain. The trafficking of MMs has been shown to be important for tissue repair and recovery. The purpose of the study is to investigate whether the BW reduction is essential for MM-mediated immune response for mice to survive and whether a corticosterone-mediated catabolic event underlies the processes. Methods- C57BL/6 male mice (12-week-old) were subjected to transient middle cerebral artery occlusion. BW, total MMs, and their Ly-6C

Indexed as

AnimalsBrainCorticosteroneDisease Models, AnimalInfarction, Middle Cerebral ArteryMacrophagesMaleMice, Inbred C57BLMonocytesSpleenStrokeWeight LossCorticosteronecorticosteroneimmunitymacrophagesmonocytemortality

Identifiers

PMID31345131
PMCPMC6710102
OpenAlexW2964448416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.