Evidence map›Paper›PMID 31345090›Full record

ArticleAutophagy2019

Gene essentiality of

Xu Xu, Dantong Shang, Hanhua Cheng, Daniel J Klionsky, Rongjia Zhou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Guideline
  2. Clinical Significance of TUBGCP4 Expression in Hepatocellular Carcinoma.Analytical cellular pathology (Amsterdam) · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Xu XuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University , Wuhan , China.
Dantong ShangHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University , Wuhan , China.
Hanhua ChengHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University , Wuhan , China.
Daniel J KlionskyLife Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor , MI , USA.ORCID 0000-0002-7828-8118
Rongjia ZhouHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University , Wuhan , China.ORCID 0000-0002-9701-8009
Wuhan University · CNUniversity of Michigan · US

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

Photoreceptor degeneration and damages often lead to blindness, and the underlying molecular mechanisms are largely unknown. There is also a lot of missing information for establishing the role of macroautophagy/autophagy in the retinopathy. We recently generated knockout mouse lines of the essential gene

Indexed as

Genes, EssentialAnimalsAutophagyGene DosageGenes, LethalHumansMiceMice, KnockoutMicrotubule-Associated ProteinsPhotoreceptor Cells, VertebrateMicrotubule-Associated ProteinsTUBGCP4 protein, humanTubgcp4 protein, mouseAutophagydosage effectembryonic lethalityessential genesretina

Identifiers

PMID31345090
PMCPMC6735468
OpenAlexW2964962510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.