Evidence map›Paper›PMID 31344982›Full record

ArticleMarine drugs2019

Discovery of Primarolides A and B from Marine Fungus

Hope A Igboeli, Douglas H Marchbank, Hebelin Correa, David Overy, Russell G Kerr

Abstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Synthetic biology enabling access to designer polyketides.Current opinion in chemical biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hope A IgboeliDepartment of Chemistry, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.
Douglas H MarchbankDepartment of Chemistry, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.
Hebelin CorreaNautilus Biosciences Croda, Regis and Joan Duffy Research Centre, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada.
David OveryDepartment of Chemistry, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.
Russell G KerrDepartment of Chemistry, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada. rkerr@upei.ca.

Funding

Natural Sciences and Engineering Research Council of Canada 2304
6 · The paper itself

Abstract

Advances in whole-genome sequencing of many fungal species has revealed the presence of numerous "silent" biosynthetic genes, highlighting their potential to produce a wide variety of natural products. These silent biosynthetic genes are regulated in part by their highly condensed chromatin structure, which can be modified to allow transcription in response to external stimuli. In this study,

Indexed as

Aquatic OrganismsAscomycotaBiological ProductsChromatography, High Pressure LiquidHydroxamic AcidsMagnetic Resonance SpectroscopyMass SpectrometryOsmosisPolyketidesSodium ChlorideBiological ProductsHydroxamic AcidsPolyketidesSodium ChlorideAsteromyces cruciatusepigenetic modificationmetabolomicsnatural productsilent biosynthetic gene clusters

Identifiers

PMID31344982
PMCPMC6723326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.