Evidence map›Paper›PMID 31344970›Full record

ArticleCells2019

Sec20 is Required for Autophagic and Endocytic Degradation Independent of Golgi-ER Retrograde Transport.

Zsolt Lakatos, Péter Lőrincz, Zoltán Szabó, Péter Benkő, Lili Anna Kenéz, Tamás Csizmadia, Gábor Juhász

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Insights into human kidney function from the study of Drosophila.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  3. Drosophila Rab39 Attenuates Lysosomal Degradation.International journal of molecular sciences · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zsolt LakatosDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Péter LőrinczDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Zoltán SzabóDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Péter BenkőDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Lili Anna KenézDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Tamás CsizmadiaDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Gábor JuhászDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary. szmrt@elte.hu.
Eötvös Loránd University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory mechanisms are important to understand. Sec20/BNIP1 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) is a BH3 (Bcl-2 homology 3) domain-containing SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) protein that has been suggested to promote Golgi-ER retrograde transport, mitochondrial fission, apoptosis and mitophagy in yeast and vertebrates. Here, we show that loss of Sec20 in

Indexed as

AdipocytesAnimalsAutophagyBiological TransportDrosophilaDrosophila ProteinsEndocytosisEndoplasmic ReticulumFluorescent Antibody TechniqueGene ExpressionGene SilencingGolgi ApparatusLysosomesMembrane GlycoproteinsProteolysisVesicular Transport ProteinsDrosophila ProteinsMembrane GlycoproteinsVesicular Transport ProteinsautophagyDrosophilaendocytosislysosomeSec20secretionSyx18

Identifiers

PMID31344970
PMCPMC6721519
OpenAlexW2963972269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.