Evidence map›Paper›PMID 31344947›Full record

ArticleMolecules (Basel, Switzerland)2019

Characterization of Antimicrobial, Antioxidant, and Leishmanicidal Activities of Schiff Base Derivatives of 4-Aminoantipyrine.

Rommy Teran, Rommel Guevara, Jessica Mora, Lizeth Dobronski, Olalla Barreiro-Costa, Timo Beske, Jorge Pérez-Barrera, Ramiro Araya-Maturana, Patricio Rojas-Silva, Ana Poveda and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Organ-Specific Distribution of Bioactive Compounds inAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Rambutan (Molecules (Basel, Switzerland) · 2026
    Article
  5. Bioactive Phenolic Compounds from Rambutan (International journal of molecular sciences · 2025
    Article
  6. Article
  7. Phytochemical Composition and Biological Properties ofAntioxidants (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Novel Schiff bases of Vanillin: potent inhibitors of macrophage harboredJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rommy TeranFacultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170521, Ecuador.
Rommel GuevaraFacultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170521, Ecuador.
Jessica MoraFacultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170521, Ecuador.
Lizeth DobronskiCentro de Investigación Traslacional, Universidad De Las Américas, Quito 170503, Ecuador.
Olalla Barreiro-CostaCentro de Investigación Traslacional, Universidad De Las Américas, Quito 170503, Ecuador.
Timo BeskeInstituto de Investigación en Salud Pública y Zoonosis-CIZ, Universidad Central del Ecuador, Quito 170521, Ecuador.
Jorge Pérez-BarreraFacultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170521, Ecuador.
Ramiro Araya-MaturanaInstituto de Química de Recursos Naturales, Programa de Investigación Asociativa en Cáncer Gástrico (PIA-CG), Universidad de Talca, Talca 3460000, Chile.
Patricio Rojas-SilvaCentro de Investigación Traslacional, Universidad De Las Américas, Quito 170503, Ecuador.
Ana PovedaFacultad de Ciencias Químicas, Universidad Central del Ecuador, Quito 170521, Ecuador. apoveda@uce.edu.ec.
Jorge Heredia-MoyaCentro de Investigación Traslacional, Universidad De Las Américas, Quito 170503, Ecuador. jorgeh.heredia@ute.edu.ec.

Funding

SENPLADES 9175.0000.0000.377784 and 91750000.0000.375239Universidad Central del Ecuador (Dirección General de Investigación y Proyectos-DGIP, project #6); project #6Universidad las Américas xxUniversidad UTE xx
6 · The paper itself

Abstract

Our main interest is the characterization of compounds to support the development of alternatives to currently marketed drugs that are losing effectiveness due to the development of resistance. Schiff bases are promising biologically interesting compounds having a wide range of pharmaceutical properties, including anti-inflammatory, antipyretic, and antimicrobial activities, among others. In this work, we have synthesized 12 Schiff base derivatives of 4-aminoantipyrine. In vitro antimicrobial, antioxidant, and cytotoxicity properties are analyzed, as well as in silico predictive adsorption, distribution, metabolism, and excretion (ADME) and bioactivity scores. Results identify two potential Schiff bases: one effective against

Indexed as

AmpyroneAnimalsAnti-Infective AgentsAntioxidantsAntiprotozoal AgentsCell SurvivalDose-Response Relationship, DrugFree Radical ScavengersMiceMicrobial Sensitivity TestsMolecular StructureSchiff BasesStructure-Activity RelationshipAmpyroneAnti-Infective AgentsAntioxidantsAntiprotozoal AgentsFree Radical ScavengersSchiff Basesantimicrobial activitycytotoxicityLeishmaniaSchiff base synthesis

Identifiers

PMID31344947
PMCPMC6696115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.