ReviewJournal of clinical medicine2019
Addiction as Learned Behavior Patterns.
Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Goal-directed behavior and hippocampal activity predict real-life impact of drinking intentions in alcohol use disorder.Translational psychiatry · 2025Article
- Risky online buying-shopping behavior: The role of stress responsivity on the transfer from goal-directed behavior to stimulus-response habits.Journal of behavioral addictions · 2025Article
- Computational mechanisms underlying the impact of Pavlovian bias on instrumental learning in problematic social media users.Journal of behavioral addictions · 2025Article
- Empowering Communities and Enhancing Public Safety: Stakeholders' Perspectives on Opioid Overdose Prevention Strategies in Boston.Community mental health journal · 2025Article
- Craving induction through virtual reality cue-exposure for patients with alcohol dependence in rehabilitation treatment.Scientific reports · 2024Article
- Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma.Neuroimage. Reports · 2024Article
- The ReCoDe addiction research consortium: Losing and regaining control over drug intake-Findings and future perspectives.Addiction biology · 2024Review
- Elevated Amygdala Responses During De Novo Pavlovian Conditioning in Alcohol Use Disorder Are Associated With Pavlovian-to-Instrumental Transfer and Relapse Latency.Biological psychiatry global open science · 2023Article
- Modifying Pavlovian-to-instrumental transfer by approach avoidance training in healthy subjects: a proof of concept study.Scientific reports · 2023Article
- Effects of a brief mindfulness meditation practice on Pavlovian-to-instrumental transfer in alcohol use disorder - a pilot study.Frontiers in psychiatry · 2023Article
- Obsessive-compulsive disorder is characterized by decreased Pavlovian influence on instrumental behavior.PLoS computational biology · 2022Article
- Effectiveness of Cue-Exposure Therapy on Alcohol Craving in Virtual Environment: Based on habit loop.Addiction & health · 2022Article
- Article
- β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue.Frontiers in behavioral neuroscience · 2022Article
- [Positive cognitive neuroscience : Positive valence systems of the Research Domain Criteria initiative].Der Nervenarzt · 2021Review
- Insights into the Neurobiology of Craving in Opioid Use Disorder.Current anesthesiology reports · 2020Article
- Food Addiction Mediates the Relationship between Perceived Stress and Body Mass Index in Taiwan Young Adults.Nutrients · 2020Article
- Alcohol Use Disorder, But Not Cannabis Use Disorder, Symptomatology in Adolescents Is Associated With Reduced Differential Responsiveness to Reward Versus Punishment Feedback During Instrumental Learning.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Alcohol Hangover Does Not Alter the Application of Model-Based and Model-Free Learning Strategies.Journal of clinical medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with substance use disorders (SUDs) have to cope with drug-related cues and contexts which can affect instrumental drug seeking, as shown with Pavlovian-to-instrumental transfer (PIT) tasks among humans and animals. Our review addresses two potential mechanisms that may contribute to habitual or even compulsive drug seeking and taking. One mechanism is represented by Pavlovian and PIT effects on drug intake. The other is a shift from goal-directed to habitual drug intake, which can be accessed via model-based versus model-free decision-making in respective learning tasks. We discuss the impact of these learning mechanisms on drug consumption. First, we describe how Pavlovian and instrumental learning mechanisms interact in drug addiction. Secondly, we address the effects of acute and chronic stress exposure on behavioral and neural PIT effects in alcohol use disorder (AUD). Thirdly, we discuss how these learning mechanisms and their respective neurobiological correlates can contribute to losing versus regaining control over drug intake. Utilizing mobile technology (mobile applications on smartphones including games that measure learning mechanisms, activity bracelets), computational models, and real-world data may help to better identify patients with a high relapse risk and to offer targeted behavioral and pharmacotherapeutic interventions for vulnerable patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.