ArticleExperimental gerontology2019
Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.
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Article in Experimental gerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Sensory decline in aging and neurodegeneration: A mitochondrial perspective.Pharmacological research · 2026Review
- Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration.iScience · 2026Article
- Age-related hearing loss involves mitochondrial DNA instability and copy number depletion in the cochlea: Insights from in vivo and in vitro models.Hearing research · 2026Article
- A mutation in Tmem135 causes progressive sensorineural hearing loss.Hearing research · 2025Article
- The Role of Calcium Signaling in Sensorineural Hearing Loss.International journal of medical sciences · 2025Review
- Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs.Frontiers in cellular neuroscience · 2025Article
- Article
- Loss ofbioRxiv : the preprint server for biology · 2024Article
- Review
- Mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with age-related hearing loss.FEBS open bio · 2023Article
- Sex differences in body composition, voluntary wheel running activity, balance performance, and auditory function in CBA/CaJ mice across the lifespan.Hearing research · 2023Article
- The roles of NADPH and isocitrate dehydrogenase in cochlear mitochondrial antioxidant defense and aging.Hearing research · 2023Review
- Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets.Frontiers in neuroscience · 2022Review
- Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging.Current environmental health reports · 2021Review
- Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss.Molecular brain · 2021Article
- Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan.Experimental gerontology · 2020Article
- Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NADAging cell · 2020Article
- Age-Related Deterioration of Mitochondrial Function in the Intestine.Oxidative medicine and cellular longevity · 2020Review
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 3 countries.
Mi-Jung KimDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Suraiya HaroonCenter for Mitochondrial and Epigenomic Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Guang-Di ChenCenter for Hearing and Deafness, State University of New York at Buffalo, NY, USA.
Dalian DingCenter for Hearing and Deafness, State University of New York at Buffalo, NY, USA.
Jonathan WanagatDepartment of Medicine, University of California, Los Angeles, CA, USA.
Lijie LiuCenter for Hearing and Deafness, State University of New York at Buffalo, NY, USA.
Yanping ZhangGene Expression & Genotyping, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA.
Karessa WhiteDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Hyo-Jin ParkDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Chul HanDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Kevin BoydDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Isabela CaicedoDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Kaitlyn EvansDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA.
Paul J LinserWhitney Laboratory, University of Florida, St Augustine, FL, USA.
Masaru TanokuraDepartment of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, Japan.
Tomas ProllaDepartment of Genetics, University of Wisconsin, Madison, WI, USA.
Richard SalviCenter for Hearing and Deafness, State University of New York at Buffalo, NY, USA; Department of Audiology and Speech-Language Pathology, Asia University, Taichung, Taiwan, ROC.
Marc VermulstCenter for Mitochondrial and Epigenomic Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shinichi SomeyaDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: someya@ufl.edu.
University of Florida · USUniversity at Buffalo, State University of New York · USUniversity of Pennsylvania · USAsia University · TWThe University of Tokyo · JPUniversity of California, Los Angeles · USUniversity of Wisconsin–Madison · US
Funding
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MUniversity of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Karyn A Esser, Todd Manini · 2007 to 2026
$22.8MUCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8MCochlear Detoxification SystemR01DC014437 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2015 to 2019
$2.2MMitochondrial biogenesis, genetics and cell loss in mammalian agingR01AG055518 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AIKEN, JUDD M., HERBST, ALLEN · 2017 to 2022
$2.0MMitochondrial Thioredoxin, Caloric Restriction, and Age-related Hearing LossR01DC012552 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2013 to 2017
$1.9MMitochondrial genetics in skeletal muscle agingK08AG032873 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANAGAT, JONATHAN · 2009 to 2013
$473kThe Role of Glutathione Reductase in Age-related Hearing LossR03DC011840 · NIDCD · UNIVERSITY OF FLORIDA · PI SOMEYA, SHINICHI · 2011 to 2013
$432kNIA NIH HHS K08 AG032873NIA NIH HHS P30 AG028740NIA NIH HHS P30 AG028748NIA NIH HHS R01 AG055518NIDCD NIH HHS R01 DC012552NIDCD NIH HHS R01 DC014437NIDCD NIH HHS R03 DC011840NIDDK NIH HHS P30 DK063491
Abstract
Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in a variety of age-related neurodegenerative diseases, including age-related hearing loss (AHL). In the current study, we investigated the roles of mtDNA deletions and point mutations in AHL in mitochondrial mutator mice (Polg
Indexed as
AnimalsDNA, MitochondrialDNA Polymerase gammaFemaleMaleMice, Inbred C57BLMice, Inbred CBAPoint MutationPresbycusisSequence DeletionSpiral GanglionDNA, MitochondrialDNA Polymerase gammaPolg protein, mouseAgingHearing lossMitochondrial diseaseMitochondrial DNA mutations
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.