ArticleFitoterapia2019
Vochysiamides A and B: Two new bioactive carboxamides produced by the new species Diaporthe vochysiae.
Article in Fitoterapia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Comprehensive genome analysis of twoMycoKeys · 2025Article
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- EndophyticFungal systematics and evolution · 2024Article
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- Genomic and Untargeted Metabolomic Analysis of Secondary Metabolites in theJournal of agricultural and food chemistry · 2024Article
- Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms.Antibiotics (Basel, Switzerland) · 2024Review
- Green-Synthesized Silver Nanoparticles in the Prevention of Multidrug-Resistant Proteus mirabilis Infection and Incrustation of Urinary Catheters BioAgNPs Against P. mirabilis Infection.Current microbiology · 2024Article
- Highly diverse endophytic fungi from Serra do Amolar-Pantanal (Brazil) producing bioactive secondary metabolites against phytopathogens.Frontiers in microbiology · 2024Article
- Potential of Secondary Metabolites ofJournal of fungi (Basel, Switzerland) · 2023Review
- Metabolomic Strategies to Improve Chemical Information from OSMAC Studies of Endophytic Fungi.Metabolites · 2023Article
- Four new endophytic species ofMycoKeys · 2023Article
- Endophytic Fungi as a Source of Antibacterial Compounds-A Focus on Gram-Negative Bacteria.Antibiotics (Basel, Switzerland) · 2022Review
- Insights into taxonomic diversity and bioprospecting potential of Cerrado endophytic fungi: a review exploring an unique Brazilian biome and methodological limitations.World journal of microbiology & biotechnology · 2022Review
- New Carboxamides and a New Polyketide from the Sponge-Derived FungusMarine drugs · 2022Article
- Fungal Endophytes: A Potential Source of Antibacterial Compounds.Journal of fungi (Basel, Switzerland) · 2022Review
- New polyketides from the liquid culture ofMycoKeys · 2022Article
- Biotransformation ability of endophytic fungi: from species evolution to industrial applications.Applied microbiology and biotechnology · 2021Review
- Potential of EndophyticJournal of microbiology and biotechnology · 2021Review
- Morphology Characterization, Molecular Phylogeny, and Pathogenicity ofPlants (Basel, Switzerland) · 2021Article
- Bioactive Secondary Metabolites of the GenusMicroorganisms · 2021Review
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8 authors.
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Abstract
Endophytic fungi have been considered a rich source for bioactive secondary metabolites with novel chemical structures. A high diverse group of endophytes, isolated from different medicinal plants, belongs to the genus Diaporthe. In a previously study performed by our group the crude extract of strain LGMF1583 showed considerable antibacterial activity mainly against Gram-negative bacteria. Based on ITS phylogeny analysis, strain LGMF1583 was identified as belonging to Diaporthe genus and may represent a new species. In the present study, we described the new species Diporthe vochysiae based on multilocus phylogeny analysis and morphological characteristics. The species name refers to the host, from which strain LGMF1583 was isolated, the medicinal plant Vochysia divergens. In view of the biotechnological potential of strain LGMF1583, we have also characterized the secondary metabolites produced by D. vochysiae. Chemical assessment of the D. vochysiae LGMF1583 revealed two new carboxamides, vochysiamides A (1) and B (2), in addition to the known metabolite, 2,5-dihydroxybenzyl alcohol (3). In the biological activity analysis, vochysiamide B (2) displayed considerable antibacterial activity against the Gram-negative bacterium Klebsiella pneumoniae (KPC), a producer of carbapenemases, MIC of 80 μg/mL. Carbapenemases are considered a major antimicrobial resistance threat, and infections caused by KPC have been considered a public health problem worldwide, and new compounds with activity against this bacterium are nowadays even more required.
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