ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Projected Population Benefit of Increased Effectiveness and Coverage of Influenza Vaccination on Influenza Burden in the United States.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Text Message Reminders for the Second Dose of Influenza Vaccine for Children: An RCT.Pediatrics · 2022Trial
- Effect of State Immunization Information System Based Reminder/Recall for Influenza Vaccinations: A Randomized Trial of Autodialer, Text, and Mailed Messages.The Journal of pediatrics · 2020Trial
- Centralized Reminder/Recall to Increase Influenza Vaccination Rates: A Two-State Pragmatic Randomized Trial.Academic pediatrics · 2020Trial
- Estimated impact of 2022-2023 influenza vaccines on annual hospital burden in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Influenza Vaccine Effectiveness During the 2023/2024 Season: A Test-Negative Case-Control Study Among Emergency Hospital Admissions With Respiratory Conditions in Northern Ireland.Influenza and other respiratory viruses · 2025Article
- Influenza Vaccination, Household Composition, and Race-Based Differences in Influenza Incidence: An Agent-Based Modeling Study.American journal of public health · 2025Article
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- Hospitalizations and emergency attendance averted by influenza vaccination in Victoria, Australia, 2017 - 2019.Epidemiology and infection · 2024Article
- Mathematical modeling for estimating influenza vaccine efficacy: A case study of the Valencian Community, Spain.Infectious Disease Modelling · 2024Article
- Interim Estimates of 2023-24 Seasonal Influenza Vaccine Effectiveness - United States.MMWR. Morbidity and mortality weekly report · 2024Article
- What motivates adults to accept influenza vaccine? An assessment of incentives, ease of access, messaging, and sources of information using a discrete choice experiment.SSM - population health · 2023Article
- Article
- Prevalence of influenza-specific vaccination hesitancy among adults in the United States, 2018.Vaccine · 2023Article
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- Article
- Risk factors and medical resource utilization in US adults hospitalized with influenza or respiratory syncytial virus in the Hospitalized Acute Respiratory Tract Infection study.Influenza and other respiratory viruses · 2022Article
- Impact of vaccine effectiveness and coverage on preventing large mumps outbreaks on college campuses: Implications for vaccination strategy.Epidemics · 2022Article
- Effectiveness of Influenza Vaccine for Preventing Laboratory-Confirmed Influenza Hospitalizations in Immunocompromised Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Projected impact of a plant-derived vaccine on the burden of seasonal influenza in Canada.Human vaccines & immunotherapeutics · 2021Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVaccination is the best way to prevent influenza; however, greater benefits could be achieved. To help guide research and policy agendas, we aimed to quantify the magnitude of influenza disease that would be prevented through targeted increases in vaccine effectiveness (VE) or vaccine coverage (VC).
methodsFor 3 influenza seasons (2011-12, 2015-16, and 2017-18), we used a mathematical model to estimate the number of prevented influenza-associated illnesses, medically attended illnesses, and hospitalizations across 5 age groups. Compared with estimates of prevented illness during each season, given observed VE and VC, we explored the number of additional outcomes that would have been prevented from a 5% absolute increase in VE or VC or from achieving 60% VE or 70% VC.
resultsDuring the 2017-18 season, compared with the burden already prevented by influenza vaccination, a 5% absolute VE increase would have prevented an additional 1 050 000 illnesses and 25 000 hospitalizations (76% among those aged ≥65 years), while achieving 60% VE would have prevented an additional 190 000 hospitalizations. A 5% VC increase would have resulted in 785 000 fewer illnesses (56% among those aged 18-64 years) and 11 000 fewer hospitalizations; reaching 70% would have prevented an additional 39 000 hospitalizations.
conclusionsSmall, attainable improvements in effectiveness or VC of the influenza vaccine could lead to substantial additional reductions in the influenza burden in the United States. Improvements in VE would have the greatest impact in reducing hospitalizations in adults aged ≥65 years, and VC improvements would have the largest benefit in reducing illnesses in adults aged 18-49 years.
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