ArticlePLoS genetics2019
RPW8/HR repeats control NLR activation in Arabidopsis thaliana.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Harnessing Natural Diversity and Rational Design for Enhanced Plant Immunity.Plant, cell & environment · 2026Review
- Genome-Wide Analysis of thePlants (Basel, Switzerland) · 2026Article
- Fine-mapping, candidate gene identification, and marker development for the apple scab resistance gene Rvi2.Journal of experimental botany · 2026Article
- The molecular evolutionary basis of species formation revisited.Trends in genetics : TIG · 2025Review
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- LHP1 and INO80 cooperate with ethylene signaling for warm ambient temperature response by activating specific bivalent genes.Cell reports · 2024Article
- Phenotypic characterization and gene mapping of hybrid necrosis in Triticum durum-Haynaldia villosa amphiploids.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages.The Plant cell · 2024Article
- WRR4B contributes to a broad-spectrum disease resistance against powdery mildew in Arabidopsis.Molecular plant pathology · 2024Article
- Programmed Cell Death in Unicellular Versus Multicellular Organisms.Annual review of genetics · 2023Review
- The Hypersensitive Response to Plant Viruses.Viruses · 2023Review
- Genetic and molecular analysis of stem rot (Sclerotinia sclerotiorum) resistance in Brassica napus (canola type).Heliyon · 2023Article
- The role of gene presence-absence variations on genetic incompatibility in Asian rice.The New phytologist · 2023Article
- The Arabidopsis thaliana onset of leaf death 12 mutation in the lectin receptor kinase P2K2 results in an autoimmune phenotype.BMC plant biology · 2023Article
- Generating minimum set of gRNA to cover multiple targets in multiple genomes with MINORg.Nucleic acids research · 2023Article
- Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants.Cell death and differentiation · 2023Review
- Predicting Cloned Disease Resistance Gene Homologs (CDRHs) in Radish, Underutilised Oilseeds, and Wild Brassicaceae Species.Plants (Basel, Switzerland) · 2022Article
- Article
- Thirty years of resistance: Zig-zag through the plant immune system.The Plant cell · 2022Review
- Plant autoimmunity-fresh insights into an old phenomenon.Plant physiology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many plant species, conflicts between divergent elements of the immune system, especially nucleotide-binding oligomerization domain-like receptors (NLR), can lead to hybrid necrosis. Here, we report deleterious allele-specific interactions between an NLR and a non-NLR gene cluster, resulting in not one, but multiple hybrid necrosis cases in Arabidopsis thaliana. The NLR cluster is RESISTANCE TO PERONOSPORA PARASITICA 7 (RPP7), which can confer strain-specific resistance to oomycetes. The non-NLR cluster is RESISTANCE TO POWDERY MILDEW 8 (RPW8) / HOMOLOG OF RPW8 (HR), which can confer broad-spectrum resistance to both fungi and oomycetes. RPW8/HR proteins contain at the N-terminus a potential transmembrane domain, followed by a specific coiled-coil (CC) domain that is similar to a domain found in pore-forming toxins MLKL and HET-S from mammals and fungi. C-terminal to the CC domain is a variable number of 21- or 14-amino acid repeats, reminiscent of regulatory 21-amino acid repeats in fungal HET-S. The number of repeats in different RPW8/HR proteins along with the sequence of a short C-terminal tail predicts their ability to activate immunity in combination with specific RPP7 partners. Whether a larger or smaller number of repeats is more dangerous depends on the specific RPW8/HR autoimmune risk variant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.