ArticleJournal of applied physiology (Bethesda, Md. : 1985)2019
Cellular and morphological changes with EAA supplementation before and after total knee arthroplasty.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02145949 (Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Peri-operative protein or amino acid supplementation for total joint arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Pooled it
- Trial
- A semi-automated pipeline for quantitation of Pax7+, myonuclei, and cross-sectional area by fiber type.Physiological reports · 2026Article
- Inflammatory Biomarkers Following Orthopedic Surgery: Current Evidence, Clinical Applications, and Future Perspectives-A Narrative Review.Journal of clinical medicine · 2026Review
- Protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes following orthopaedic surgery.Experimental physiology · 2025Review
- Unraveling the bidirectional relationship between muscle inflammation and satellite cells activity: influencing factors and insights.Journal of muscle research and cell motility · 2025Review
- Adoption and acceptability of a perioperative nutrition program among total joint arthroplasty patients.Frontiers in health services · 2025Article
- The role of amino acids in skeletal muscle health and sarcopenia: A narrative review.Journal of biomedical research · 2024Article
- Review
- Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation.Current osteoporosis reports · 2023Review
- Article
- Use of Conditionally Essential Amino Acids and the Economic Burden of Postoperative Complications After Fracture Fixation: Results from a Cost Utility Analysis.ClinicoEconomics and outcomes research : CEOR · 2023Article
- Nutritional Regulation of Muscle Stem Cells in Exercise and Disease: The Role of Protein and Amino Acid Dietary Supplementation.Frontiers in physiology · 2022Review
- Muscle fibrosis and maladaptation occur progressively in CKD and are rescued by dialysis.JCI insight · 2021Article
- Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery.Nutrients · 2021Review
- Essential amino acid supplementation alters the p53 transcriptional response and cytokine gene expression following total knee arthroplasty.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Investigate the underlying cellular basis of muscle atrophy (Placebo) and atrophy reduction (essential amino acid supplementation, EAAs) in total knee arthroplasty (TKA) patients by examining satellite cells and other key histological markers of inflammation, recovery, and fibrosis. Forty-one subjects (53-76 yr) scheduled for TKA were randomized into two groups, ingesting 20 g of EAAs or placebo, twice-daily, for 7 days before TKA and for 6 wk after surgery. A first set of muscle biopsies was obtained from both legs before surgery in the operating room, and patients were randomly assigned and equally allocated to have two additional biopsies at either 1 or 2 wk after surgery. Biopsies were processed for gene expression and immunohistochemistry. Satellite cells were significantly higher in patients ingesting 20 g of essential amino acids twice daily for the 7 days leading up to surgery compared with Placebo (operative leg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.