ArticleJournal of biophotonics2019
Translational optical coherence elastography for assessment of systemic sclerosis.
Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Quantifying age and spatial variations of bone marrow elasticity with noncontact optical coherence elastography.Journal of biomedical optics · 2025Article
- ALK5 inhibitor impact on bleomycin-induced systemic sclerosis mouse model via multifunctional optical coherence tomography.APL bioengineering · 2025Article
- Optical coherence elastography detects increased corneal stiffness in nonhuman primates with experimental glaucoma.Journal of biomedical optics · 2025Article
- Convolutional Neural Networks Enable Direct Strain Estimation in Quasistatic Optical Coherence Elastography.Journal of biophotonics · 2025Article
- Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography.Journal of biomedical optics · 2025Article
- Dual optical elastography detectsJournal of biomedical optics · 2024Article
- Motion-artifact-free single shot two-beam optical coherence elastography system.Journal of biomedical optics · 2024Article
- VP-net: an end-to-end deep learning network for elastic wave velocity prediction in human skinFrontiers in bioengineering and biotechnology · 2024Article
- Spatial frequency domain imaging for the assessment of scleroderma skin involvement.Biomedical optics express · 2023Article
- Systemic sclerosis.Lancet (London, England) · 2023Review
- In vivo stiffness measurement of epidermis, dermis, and hypodermis using broadband Rayleigh-wave optical coherence elastography.Acta biomaterialia · 2022Article
- Skin involvement in early diffuse cutaneous systemic sclerosis: an unmet clinical need.Nature reviews. Rheumatology · 2022Review
- Introduction to optical coherence elastography: tutorial.Journal of the Optical Society of America. A, Optics, image science, and vision · 2022Article
- Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022Article
- Ultra-fast dynamic line-field optical coherence elastography.Optics letters · 2021Article
- Ultrasound Shear Wave Elastography and Transient Optical Coherence Elastography: Side-by-Side Comparison of Repeatability and Accuracy.IEEE open journal of engineering in medicine and biology · 2021Article
- Ultra-sensitive optical coherence elastography using a high-dynamic-range force loading scheme for cervical rigidity assessment.Biomedical optics express · 2020Article
- Optical elastography and tissue biomechanics.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Systemic sclerosis (SSc-scleroderma) is an autoimmune disorder with high mortality rate that results in excessive accumulation of collagen in the skin and internal organs. Currently, the modified Rodnan Skin Score (mRSS) is the gold standard for evaluating the dermal thickening due to SSc. However, mRSS has noticeable inter- and intra-observer variabilities as quantified by the interclass correlation coefficient (ICC: 0.6-0.75). In this work, optical coherence elastography (OCE) combined with structural optical coherence tomography (OCT) image analysis was used to assess skin thickness in 12 SSc patients and healthy volunteers. Inter- (ICC: 0.62-0.99) and intra-observer (ICC > 0.90) assessment of OCT/OCE showed excellent reliability. Clinical assessments, including histologically assessed dermal thickness (DT), mRSS, and site-specific mRSS (SMRSS) were also performed for further validation. The OCE and OCT results from the forearm demonstrated the highest correlation (OCE: 0.78, OCT: 0.65) with SMRSS. Importantly, OCE and OCT had stronger correlations with the histological DT (OCT: r = .78 and OCE: r = .74) than SMRSS (r = .57), indicating the OCT/OCE could outperform semi-quantitative clinical assessments such as SMRSS. Overall, these results demonstrate that OCT/OCE could be useful for rapid, noninvasive and objective assessments of SSc onset and monitoring skin disease progression and treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.