Evidence map›Paper›PMID 31343413›Full record

ArticleAging2019

Profiling of mRNA of interstitial fibrosis and tubular atrophy with subclinical inflammation in recipients after kidney transplantation.

Qiang Fu, Minxue Liao, Cheng Feng, Jichao Tang, Rui Liao, Liang Wei, Hongji Yang, James F Markmann, Kai Chen, Shaoping Deng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. How Cytokines Regulate Immune Response Toward Chronic Allograft Rejection?Results and problems in cell differentiation · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Mechanism of transforming growth factor-Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Qiang FuOrgan Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine of University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
Minxue LiaoOrgan Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine of University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
Cheng FengOrgan Transplantation Translational Medicine Key Laboratory of Sichuan Province, Chengdu 610072, Sichuan, China.
Jichao TangOrgan Transplantation Translational Medicine Key Laboratory of Sichuan Province, Chengdu 610072, Sichuan, China.
Rui LiaoOrgan Transplantation Translational Medicine Key Laboratory of Sichuan Province, Chengdu 610072, Sichuan, China.
Liang WeiOrgan Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine of University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
Hongji YangOrgan Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine of University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
James F MarkmannTransplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02148, USA.
Kai ChenOrgan Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine of University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
Shaoping DengOrgan Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine of University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
Science and Technology Department of Sichuan Province · CNUniversity of Electronic Science and Technology of China · CNMassachusetts General Hospital · USNorth Sichuan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interstitial fibrosis and tubular atrophy (IFTA) with inflammation (IFTA-I) is strongly correlated with kidney allograft failure. Diagnosis of IFTA-I accurately and early is critical to prevent graft failure and improve graft survival. In the current study, through analyzing the renal allograft biopsy in patients with stable function after kidney transplantation (STA), IFTA and IFTA-I group with semi-supervised principal components methods, we found that CD2, IL7R, CCL5 based signature could not only distinguish STA and IFTA-I well, but predict IFTA-I with a high degree of accuracy with an area under the curve (AUC) of 0.91 (

Indexed as

Adaptor Proteins, Signal TransducingAdultArea Under CurveAtrophyBiomarkersBiopsyChemokine CCL5Cytoskeletal ProteinsFemaleFibrosisGene Expression ProfilingGraft RejectionHumansInterferon Regulatory Factor-8Interferon Regulatory FactorsInterleukin-7 Receptor alpha SubunitAdaptor Proteins, Signal TransducingBiomarkersCCL5 protein, humanCD2-associated proteinChemokine CCL5Cytoskeletal ProteinsIL7R protein, humanInterferon Regulatory Factor-8Interferon Regulatory FactorsInterleukin-7 Receptor alpha SubunitRNA, Messengerinterstitial fibrosis and tubular atrophy (IFTA)interstitial fibrosis and tubular atrophy with subclinical inflammation (IFTA-I)IRF8kidney transplantation

Identifiers

PMID31343413
PMCPMC6682514
OpenAlexW2963295403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.