ArticleeLife2019
Primate prefrontal neurons signal economic risk derived from the statistics of recent reward experience.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Value coding by primate amygdala neurons complies with the continuity axiom of economic choice theory.Journal of neurophysiology · 2026Article
- Interpersonal brain synchronization at frontopolar cortices underlies better advice-taking in groups.Social cognitive and affective neuroscience · 2026Article
- Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.Nature communications · 2025Article
- Population coding of strategic variables during foraging in freely moving macaques.Nature neuroscience · 2024Article
- Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys.Cognitive, affective & behavioral neuroscience · 2023Article
- Nutrient-Sensitive Reinforcement Learning in Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Decision neuroscience and neuroeconomics: Recent progress and ongoing challenges.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system.Nature communications · 2022Article
- Article
- Reward uncertainty asymmetrically affects information transmission within the monkey fronto-parietal network.Communications biology · 2020Article
- Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction.Nature communications · 2020Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Risk derives from the variation of rewards and governs economic decisions, yet how the brain calculates risk from the frequency of experienced events, rather than from explicit risk-descriptive cues, remains unclear. Here, we investigated whether neurons in dorsolateral prefrontal cortex process risk derived from reward experience. Monkeys performed in a probabilistic choice task in which the statistical variance of experienced rewards evolved continually. During these choices, prefrontal neurons signaled the reward-variance associated with specific objects ('object risk') or actions ('action risk'). Crucially, risk was not derived from explicit, risk-descriptive cues but calculated internally from the variance of recently experienced rewards. Support-vector-machine decoding demonstrated accurate neuronal risk discrimination. Within trials, neuronal signals transitioned from experienced reward to risk (risk updating) and from risk to upcoming choice (choice computation). Thus, prefrontal neurons encode the statistical variance of recently experienced rewards, complying with formal decision variables of object risk and action risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.