Evidence map›Paper›PMID 31343405›Full record

ArticleeLife2019

Mechanism of pharmacochaperoning in a mammalian K

Gregory M Martin, Min Woo Sung, Zhongying Yang, Laura M Innes, Balamurugan Kandasamy, Larry L David, Craig Yoshioka, Show-Ling Shyng

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
  2. Article
  3. Inhibition Mechanism of Pancreatic KResearch (Washington, D.C.) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. A fluorescent probe for the enzymatic activity of KbioRxiv : the preprint server for biology · 2025
    Article
  8. Bayliss-Starling Prize Lecture: KThe Journal of physiology · 2025
    Article
  9. Article
  10. Dynamic duo: Kir6 and SUR in KChannels (Austin, Tex.) · 2024
    Review
  11. Article
  12. Structure of an open KNature communications · 2024
    Article
  13. Article
  14. Non-radioactive RbMethods in molecular biology (Clifton, N.J.) · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. KCurrent opinion in structural biology · 2023
    Review
  19. Article
  20. Personalized Therapeutics for KAnnual review of pharmacology and toxicology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gregory M Martin *Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, United States.
Min Woo Sung *Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, United States.
Zhongying YangDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, United States.
Laura M InnesDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, United States.
Balamurugan KandasamyDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, United States.
Larry L DavidDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, United States.
Craig YoshiokaDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, United States.ORCID 0000-0002-0251-7316
Show-Ling ShyngDepartment of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, United States.ORCID 0000-0002-8230-8820
Oregon Health & Science University · US

Funding

Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Luiz Eduardo Bertassoni · 1997 to 2026
$60.5M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
KATP channels and insulin secretionR01DK057699 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2001 to 2019
$6.1M
Structural Basis of KATP Channel GatingR01DK066485 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2006 to 2024
$5.8M
LTQ Orbitrap VelosS10OD012246 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVID, LARRY L · 2012 to 2012
$854k
Pharmacological rescue of trafficking-impaired KATP channelsF31DK105800 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MARTIN, GREGORY M · 2015 to 2017
$131k
NEI NIH HHS P30 EY010572NIDDK NIH HHS F31 DK105800NIDDK NIH HHS R01 DK057699NIDDK NIH HHS R01 DK066485NIH HHS DK066485NIH HHS DK57699NIH HHS S10 OD012246
6 · The paper itself

Abstract

ATP-sensitive potassium (K

Indexed as

Cryoelectron MicroscopyAnimalsBinding SitesCarbamatesCell LineCricetinaeCysteineGlyburideHumansKATP ChannelsKcnj11 ChannelMammalsModels, MolecularMutationPharmaceutical PreparationsPiperidinesCarbamatesCysteineGlyburideKATP ChannelsKcnj11 ChannelPharmaceutical PreparationsPiperidinesPotassium Channels, Inwardly RectifyingrepaglinideABC transportercarbamazepineglibenclamideinward rectifier potassium channelmolecular biophysicsratrepaglinidestructural biologysulfonylurea receptor

Identifiers

PMID31343405
PMCPMC6699824
OpenAlexW2963721661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.