Evidence map›Paper›PMID 31343174›Full record

ArticleJournal of natural products2019

Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation.

Ana S C Valdeira, Emad Darvishi, Girma M Woldemichael, John A Beutler, Kirk R Gustafson, Jorge A R Salvador

Abstract read
In one paragraph

Article in Journal of natural products, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Investigating the role of cytochromeRSC medicinal chemistry · 2026
    Article
  3. Review
  4. Asiatic Acid fromBiomolecules · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Morphological, phytochemical and genetic characterization ofSaudi journal of biological sciences · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Madecassic Acid-A New Scaffold for Highly Cytotoxic Agents.International journal of molecular sciences · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana S C ValdeiraLaboratory of Pharmaceutical Chemistry, Faculty of Pharmacy , University of Coimbra , 3000-548 Coimbra , Portugal.ORCID 0000-0001-8227-2170
Emad DarvishiMolecular Targets Program, Center for Cancer Research , National Cancer Institute , Frederick , Maryland 21702 , United States.
Girma M WoldemichaelMolecular Targets Program, Center for Cancer Research , National Cancer Institute , Frederick , Maryland 21702 , United States.
John A BeutlerMolecular Targets Program, Center for Cancer Research , National Cancer Institute , Frederick , Maryland 21702 , United States.ORCID 0000-0002-4646-1924
Kirk R GustafsonMolecular Targets Program, Center for Cancer Research , National Cancer Institute , Frederick , Maryland 21702 , United States.ORCID 0000-0001-6821-4943
Jorge A R SalvadorLaboratory of Pharmaceutical Chemistry, Faculty of Pharmacy , University of Coimbra , 3000-548 Coimbra , Portugal.ORCID 0000-0003-0779-6083

Funding

Natural Products Discovery and Characterization Through Network CollaborationsZIABC011568 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DU, LIN · 2014 to 2025
$17.2M
Development of Natural Product Leads as Anticancer TherapeuticsZIABC011470 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC011470Intramural NIH HHS ZIA BC011568NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

A series of novel madecassic acid (

Indexed as

Antineoplastic AgentsCell CycleCell Line, TumorCell ProliferationHumansMolecular StructureSpectrum AnalysisStructure-Activity RelationshipTriterpenesAntineoplastic Agentsmadecassic acidTriterpenes

Identifiers

PMID31343174
PMCPMC7428852

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.