Evidence map›Paper›PMID 31342985›Full record

ArticleDalton transactions (Cambridge, England : 2003)2019

Dialing in on pharmacological features for a therapeutic antioxidant small molecule.

Kayla N Green, Kristof Pota, Gyula Tircsó, Réka Anna Gogolák, Olivia Kinsinger, Collin Davda, Kimberly Blain, Samantha M Brewer, Paulina Gonzalez, Hannah M Johnston and 1 more

Abstract read
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Predicting pRSC advances · 2025
    Article
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  12. Stabilisation of Exotic Tribromide (BrMolecules (Basel, Switzerland) · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kayla N GreenDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA. kayla.green@tcu.edu.ORCID http://orcid.org/0000-0001-8816-7646
Kristof PotaDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA. kayla.green@tcu.edu.
Gyula TircsóDepartment of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, H-4010, Hungary.ORCID http://orcid.org/0000-0002-7896-7890
Réka Anna GogolákDepartment of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, Debrecen, H-4010, Hungary.
Olivia KinsingerDepartment of Biology, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA.
Collin DavdaDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA. kayla.green@tcu.edu.
Kimberly BlainDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA. kayla.green@tcu.edu and Department of Biology, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA.
Samantha M BrewerDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA. kayla.green@tcu.edu.
Paulina GonzalezDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA. kayla.green@tcu.edu.
Hannah M JohnstonDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA. kayla.green@tcu.edu.
Giridhar AkkarajuDepartment of Biology, Texas Christian University, 2950 S. Bowie, Fort Worth, TX 76129, USA.

Funding

Targeting oxidative stress in neurodegeneration using pyridol-derived small moleculesR15GM123463 · NIGMS · TEXAS CHRISTIAN UNIVERSITY · PI AKKARAJU, GIRIDHAR, CHUMLEY, MICHAEL J · 2018 to 2025
$1.2M
NIGMS NIH HHS R15 GM123463
6 · The paper itself

Abstract

The pyridinophane molecule L2 (3,6,9,15-tetraazabicyclo[9.3.1]penta-deca-1(15),11,13-trien-13-ol) has shown promise as a therapuetic for neurodegenerative diseases involving oxidative stress and metal ion misregulation. Protonation and metal binding stability constants with Mg

Indexed as

AnimalsAntioxidantsCells, CulturedCell SurvivalDose-Response Relationship, DrugLigandsMaleMiceMice, Inbred ICRMolecular StructureOrganoplatinum CompoundsSmall Molecule LibrariesStructure-Activity RelationshipAntioxidantsLigandsOrganoplatinum CompoundsSmall Molecule Libraries

Identifiers

PMID31342985
PMCPMC6863055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.