Evidence map›Paper›PMID 31342895›Full record

SynthesisMutation research. Reviews in mutation research

Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence.

Luoping Zhang, Iemaan Rana, Rachel M Shaffer, Emanuela Taioli, Lianne Sheppard

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Mutation research. Reviews in mutation research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 9 pooled it
58.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 9 syntheses or guidelines pooled it, 352 citations in OpenAlex.

  1. Pooled it
  2. Early exposure to agricultural pesticides and the occurrence of autism spectrum disorder: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022
    Pooled it
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  4. Cancer and occupational exposure to pesticides: an umbrella review.International archives of occupational and environmental health · 2021
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Luoping ZhangDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, USA. Electronic address: luoping@berkeley.edu.
Iemaan RanaDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, USA.
Rachel M ShafferDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA.
Emanuela TaioliInstitute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA.
Lianne SheppardDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA; Department of Biostatistics, University of Washington, Seattle, USA.
Berkeley Public Health Division · USUniversity of Washington · USIcahn School of Medicine at Mount Sinai · US

Funding

Biostatistics, Epidemiologic & Bioinformatic Training in Environmental HealthT32ES015459 · NIEHS · UNIVERSITY OF WASHINGTON · PI June T. Spector · 2009 to 2026
$10.6M
NIEHS NIH HHS T32 ES015459
6 · The paper itself

Abstract

Glyphosate is the most widely used broad-spectrum systemic herbicide in the world. Recent evaluations of the carcinogenic potential of glyphosate-based herbicides (GBHs) by various regional, national, and international agencies have engendered controversy. We investigated whether there was an association between high cumulative exposures to GBHs and increased risk of non-Hodgkin lymphoma (NHL) in humans. We conducted a new meta-analysis that includes the most recent update of the Agricultural Health Study (AHS) cohort published in 2018 along with five case-control studies. Using the highest exposure groups when available in each study, we report the overall meta-relative risk (meta-RR) of NHL in GBH-exposed individuals was increased by 41% (meta-RR = 1.41, 95% confidence interval, CI: 1.13-1.75). For comparison, we also performed a secondary meta-analysis using high-exposure groups with the earlier AHS (2005), and we calculated a meta-RR for NHL of 1.45 (95% CI: 1.11-1.91), which was higher than the meta-RRs reported previously. Multiple sensitivity tests conducted to assess the validity of our findings did not reveal meaningful differences from our primary estimated meta-RR. To contextualize our findings of an increased NHL risk in individuals with high GBH exposure, we reviewed publicly available animal and mechanistic studies related to lymphoma. We documented further support from studies of malignant lymphoma incidence in mice treated with pure glyphosate, as well as potential links between glyphosate / GBH exposure and immunosuppression, endocrine disruption, and genetic alterations that are commonly associated with NHL or lymphomagenesis. Overall, in accordance with findings from experimental animal and mechanistic studies, our current meta-analysis of human epidemiological studies suggests a compelling link between exposures to GBHs and increased risk for NHL.

Indexed as

CarcinogensGlycineGlyphosateHerbicidesHumansLymphoma, Non-HodgkinRiskCarcinogensGlycineGlyphosateHerbicidesCarcinogenesisGlyphosateMeta-analysisPesticideRanger proRoundup

Identifiers

PMID31342895
PMCPMC6706269
OpenAlexW2912637713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.