Evidence map›Paper›PMID 31342740›Full record

ArticleBiomacromolecules2019

Nonviral Nanoparticles for CRISPR-Based Genome Editing: Is It Just a Simple Adaption of What Have Been Developed for Nucleic Acid Delivery?

Min Qiu, Zachary Glass, Qiaobing Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing ofProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Min QiuDepartment of Biomedical Engineering , Tufts University , 4 Colby Street , Medford , Massachusetts 02155 , United States.
Zachary GlassDepartment of Biomedical Engineering , Tufts University , 4 Colby Street , Medford , Massachusetts 02155 , United States.
Qiaobing XuDepartment of Biomedical Engineering , Tufts University , 4 Colby Street , Medford , Massachusetts 02155 , United States.ORCID 0000-0001-7323-7795

Funding

Efficient in Vivo RNP-based Gene Editing in the Sensory Organ Inner Ear Using Bioreducible Lipid NanoparticlesUG3TR002636 · NCATS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI CHEN, ZHENG-YI, LIU, DAVID R · 2018 to 2020
$2.4M
ROS-responsive Chemical Modification of Protein and Its DeliveryR01EB027170 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI XU, QIAOBING · 2018 to 2022
$1.4M
NCATS NIH HHS UG3 TR002636NIBIB NIH HHS R01 EB027170
6 · The paper itself

Abstract

Genome-editing technologies hold tremendous potential for treating genetic diseases. However, the efficient and safe delivery of genome-editing elements to the location of interest, and the achievement of specific targeted gene correction without off-target side effect remains a big challenge. In this Perspective, we highlight recent developments and discuss the challenges of nonviral nanoparticles for the delivery of genome-editing tools. Finally, we will propose promising strategies to improve the delivery efficacy and advance the clinical translation of gene-editing technology.

Indexed as

Gene Transfer TechniquesCRISPR-Cas SystemsGene EditingGenetic TherapyHumansNanoparticlesNucleic AcidsNucleic Acids

Identifiers

PMID31342740
PMCPMC7261392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.