ArticleJournal of biomedical optics2019
Combined ultrasound and photoacoustic imaging of blood clot during microbubble-assisted sonothrombolysis.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Ultrasound-Mediated Thrombolysis: From Mechanistic Insights to Advanced Nanoplatforms and Clinical Translation.Advanced healthcare materials · 2026Review
- Advances in Platelet-Dysfunction Diagnostic Technologies.Biomolecules · 2024Review
- Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions.Advanced drug delivery reviews · 2024Review
- Therapeutic and Contrast Agents for Photoacoustic Imaging-Guided Photothermal Therapy: A Narrative Review.Nanotheranostics · 2024Review
- Ultrasound-guided needle tracking with deep learning: A novel approach with photoacoustic ground truth.Photoacoustics · 2023Article
- Looking deep inside tissue with photoacoustic molecular probes: a review.Journal of biomedical optics · 2022Review
- Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery.Biomedical engineering letters · 2022Article
- Photoacoustic imaging of 3D-printed vascular networks.Biofabrication · 2022Article
- Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.Frontiers in neuroscience · 2022Review
- SVD-based filtering to detect intraplaque hemorrhage using single wavelength photoacoustic imaging.Journal of biomedical optics · 2021Article
- SARS-CoV-2-related vascular injury: mechanisms, imaging and models.Microphysiological systems · 2021Article
- Deep learning approach to improve tangential resolution in photoacoustic tomography.Biomedical optics express · 2020Article
- Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing.Frontiers in bioengineering and biotechnology · 2019Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blockage of healthy blood vessels by blood clots can lead to serious or even life-threatening complications. The use of a combined ultrasound (US) and photoacoustic (PA) imaging was explored for blood clot monitoring during microbubble-assisted sonothrombolysis. PA imaging is an emerging hybrid imaging modality that has garnered the attention of the biomedical imaging community in recent years. It enables the study of the composition of a blood clot due to its sensitivity toward optical absorption. Here, in vitro imaging of the side of a blood clot facing the microbubbles was done over time. The US and PA signal-to-noise (SNR) ratio value changes during microbubble-assisted sonothrombolysis were studied for two different local environments: blood clot in deionized water and blood clot in blood. In the first case, US and PA SNR values increased by 4.6% and reduced by 20.8%, respectively after 30 min of sonothrombolysis treatment. After 10 min of sonothrombolysis treatment of the blood clot in blood, the US and PA SNR values increased by 7.7% and 38.3%, respectively. The US and PA SNR value changes were recorded in response to its local environment. This technique can be used to determine the final composition of the blood clot which may, in turn, help in the administration of clot-dissolving drugs.
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