Evidence map›Paper›PMID 31342606›Full record

ArticleEuropean journal of neurology2020

Objective quantification of vitreous haze on optical coherence tomography scans: no evidence for relationship between uveitis and inflammation in multiple sclerosis.

D Coric, G Ometto, G Montesano, P A Keane, L J Balk, B M J Uitdehaag, A Petzold, D P Crabb, A K Denniston

Open access · bronzeAbstract read
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In one paragraph

Article in European journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Artificial intelligence extension of the OSCAR-IB criteria.Annals of clinical and translational neurology · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

D CoricDepartment of Neurology, MS Center Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID 0000-0003-0106-9336
G OmettoOptometry and Visual Sciences, City, University of London, London, UK.
G MontesanoOptometry and Visual Sciences, City, University of London, London, UK.
P A KeaneNIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
L J BalkDepartment of Neurology, MS Center Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.ORCID 0000-0002-3915-0052
B M J UitdehaagDepartment of Neurology, MS Center Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
A PetzoldDepartment of Neurology, MS Center Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
D P CrabbOptometry and Visual Sciences, City, University of London, London, UK.
A K DennistonNIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
City, University of London · GBNetherlands Center for Occupational Diseases · NLAmsterdam Neuroscience · NLMoorfields Eye Hospital · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

Department of Health CS-2014-14-023
6 · The paper itself

Abstract

background and purposeThe occurrence of intermediate uveitis, which is characterized by the presence of vitreous haze (VH), in patients with multiple sclerosis (MS) may be a sign of coexistent inflammatory central nervous system (CNS) disease activity. Using an automated algorithm to quantify VH on optical coherence tomography (OCT) scans, the aim was to investigate whether VH in MS patients is associated with signs of inflammatory CNS disease activity.

methodsVitreous haze was quantified on OCT macular volume scans of 290 MS patients and 85 healthy controls (HCs). The relationship between VH and clinical, retinal OCT and magnetic resonance imaging parameters of inflammatory disease activity was investigated using generalized estimating equations.

resultsMean VH scores did not differ between patients and HCs (P = 0.629). Six patients (2.1%) showed values higher than the highest of the controls by HCs. VH scores did not differ between the different disease types or between eyes with and without a history of optic neuritis (P = 0.132). VH was not associated with inner nuclear layer volume on OCT (P = 0.233), cerebral T2 lesion load on magnetic resonance imaging (P = 0.416) or the development of new relapses (P = 0.205).

conclusionIn this study, OCT-based automated VH estimation did not detect increased vitreous inflammation in MS patients compared to HCs and did not find an association with CNS inflammatory burden.

Indexed as

AdolescentAdultAgedAged, 80 and overAlgorithmsFemaleHumansImage Processing, Computer-AssistedInflammationMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisOptic NeuritisRetinaTomography, Optical Coherencemultiple sclerosisneuro-ophthalmologyoptical coherence tomographyuveitisvitreous haze

Identifiers

PMID31342606
PMCPMC6916624
OpenAlexW2963154222

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.