Evidence map›Paper›PMID 31342536›Full record

Observational studyAlimentary pharmacology & therapeutics2019

The reduction of faecal calprotectin during exclusive enteral nutrition is lost rapidly after food re-introduction.

Michael Logan, Clare M Clark, Umer Zeeshan Ijaz, Lisa Gervais, Hazel Duncan, Vikki Garrick, Lee Curtis, Elaine Buchanan, Tracey Cardigan, Lawrence Armstrong and 9 more

Registry-linked trialOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Alimentary pharmacology & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05606419 (The Crohn's Disease Exclusion Diet With Early Dairy Introduction vs Partial Enteral Nutrition), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05606419 nasuspendednot on this mapstarted 2024, after this paper: background citation

The Crohn's Disease Exclusion Diet With Early Dairy Introduction vs Partial Enteral Nutrition (CD-EDEN) in Adult Patients With Crohn's Disease

TypeinterventionalSponsorEvangelismos HospitalRan2024 to 2026Enrolled44ConditionsCrohn DiseaseArmsCDED+PEN, CDED+dairy
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  15. Revolution in diet therapy for inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2024
    Review
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  20. Antibiotics (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Michael LoganCivil Engineering, School of Engineering, University of Glasgow, Glasgow, UK.ORCID 0000-0003-3967-6123
Clare M ClarkHuman Nutrition, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
Umer Zeeshan IjazCivil Engineering, School of Engineering, University of Glasgow, Glasgow, UK.
Lisa GervaisDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Hazel DuncanDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Vikki GarrickDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Lee CurtisDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Elaine BuchananDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Tracey CardiganDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Lawrence ArmstrongDepartment of Paediatrics, Crosshouse Hospital, Kilmarnock, UK.
Caroline DelahuntyDepartment of Paediatrics, Wishaw General Hospital, Wishaw, UK.
Diana M FlynnDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Andrew R BarclayDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Rachel TaylerDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Elizabeth McDonaldInstitute for Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Simon MillingInstitute for Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Richard K HansenDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.
Konstantinos GerasimidisHuman Nutrition, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
Richard K RussellDepartment of Paediatric Gastroenterology, Royal Hospital for Children, Glasgow, UK.ORCID 0000-0001-7398-4926
Royal Hospital for Children · GBGlasgow Royal Infirmary · GBWellcome Centre for Molecular Parasitology · GBUniversity Hospital Crosshouse · GBUniversity of Glasgow · GBWishaw General Hospital · GB

Funding

Engineering and Physical Sciences Research CouncilNatural Environment Research Council NE/L011956/1Nestle Health Science
6 · The paper itself

Abstract

backgroundFaecal calprotectin decreases during exclusive enteral nutrition in children with active Crohn's disease. It is unknown how faecal calprotectin changes during food re-introduction and the influence of maintenance enteral nutrition.

aimsTo study changes to faecal calprotectin during exclusive enteral nutrition and at food reintroduction, and explore associations with maintenance enteral nutrition.

methodsChildren with Crohn's disease were followed during exclusive enteral nutrition and during food-reintroduction. Faecal calprotectin was measured before, at 33 and 54 days of exclusive enteral nutrition, and at 17, 52 and 72 days after food-reintroduction. Maintenance enteral nutrition use was recorded with estimated weight food diaries. Data are presented with medians and Q1:Q3.

resultsSixty-six patients started exclusive enteral nutrition and 41 (62%) achieved clinical remission (weighted paediatric Crohn's disease activity index <12.5). Baseline faecal calprotectin (mg/kg) decreased after 4 and 8 weeks of exclusive enteral nutrition (Start: 1433 [Q1: 946, Q3: 1820] vs 33 days: 844 [314, 1438] vs 54 days: 453 [165, 1100]; P < .001). Within 17 days of food reintroduction, faecal calprotectin increased to 953 [Q1: 519, Q3: 1611] and by 52 days to 1094 [660, 1625] (both P < .02). Fifteen of 41 (37%) children in remission used maintenance enteral nutrition (333 kcal or 18% of energy intake). At 17 days of food reintroduction, faecal calprotectin was lower in maintenance enteral nutrition users than non-users (651 [Q1: 271, Q3: 1781] vs 1238 [749, 2102], P = .049) and correlated inversely with maintenance enteral nutrition volume (rho: -0.573, P = .041), kcals (rho: -0.584, P = .036) and % energy intake (rho: -0.649, P = .016). Maintenance enteral nutrition use was not associated with longer periods of remission (P = .7). Faecal calprotectin at the end of exclusive enteral nutrition did not predict length of remission.

conclusionsThe effect of exclusive enteral nutrition on faecal calprotectin is diminished early during food reintroduction. Maintenance enteral nutrition at ~18% of energy intake is associated with a lower faecal calprotectin at the early phase of food reintroduction but is ineffective in maintaining longer term remission.

Indexed as

Enteral NutritionFoodAdolescentChildCrohn DiseaseEnergy IntakeFecesFemaleHumansLeukocyte L1 Antigen ComplexMaleRemission InductionLeukocyte L1 Antigen Complex

Identifiers

PMID31342536
PMCPMC6772069
OpenAlexW2962966992

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.