Evidence map›Paper›PMID 31342529›Full record

ArticleHepatology (Baltimore, Md.)2020

Redefining Cirrhotic Cardiomyopathy for the Modern Era.

Manhal Izzy, Lisa B VanWagner, Grace Lin, Mario Altieri, James Y Findlay, Jae K Oh, Kymberly D Watt, Samuel S Lee, Cirrhotic Cardiomyopathy Consortium

Erratum issued 5 registry-linked trialsAbstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 5 registered trials, which are not on this map. Cited by 140 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04111133 naunknown statusnot on this map

Efficacy of Carvedilol + Ivabradine vs Carvedilol Alone for Left Ventricular Diastolic Dysfunction in Chronic Liver Disease Patients and Its' Impact on Morbidity and Mortality; a Prospective Randomized Controlled Trial.

TypeinterventionalSponsorPost Graduate Institute of Medical Education and Research, ChandigarhRan2020 to 2024Enrolled130ConditionsCirrhotic Cardiomyopathy, Left Ventricular Dysfunction, Cirrhosis, Liver, Portal HypertensionArmsBetablocker + ivabradine, Betablocker
NCT05059795 completednot on this map

To Compare the Effectiveness of Various Methods of Estimating Volume Resuscitation in Patients With Cirrhosis With Sepsis Induced Hypotension

TypeobservationalSponsorPost Graduate Institute of Medical Education and Research, ChandigarhRan2020 to 2025Enrolled350ConditionsCirrhosis, Liver, Sepsis, Acute on Chronic Liver FailureArmsAlbumin + electrolyte solution, POCUS guided fluid resuscitation
NCT05700708 unknown statusnot on this mapstarted 2022, after this paper: background citation

Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory Ascites

TypeobservationalSponsorPost Graduate Institute of Medical Education and Research, ChandigarhRan2022 to 2024Enrolled80ConditionsCirrhosis, Liver, Acute-On-Chronic Liver Failure, Refractory Ascites, AscitesArmsEchocardiographic assessment
NCT06095466 recruitingnot on this mapstarted 2023, after this paper: background citation

Diagnosis and Pathogenetic Mechanisms in Cirrhotic Cardiomyopathy Based on Point-of-care Echocardiography, Biomarkers and Histology

TypeobservationalSponsorPost Graduate Institute of Medical Education and Research, ChandigarhRan2023 to 2026Enrolled150ConditionsCirrhotic Cardiomyopathy, Cirrhosis, Liver, Cardiac DiseaseArmsEchocardiographic assessment, Histopathology and Immunohistochemistry
NCT07658222 recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective Investigation of Cirrhotic Cardiomyopathy in Humans

TypeobservationalSponsorVanderbilt University Medical CenterRan2026 to 2030Enrolled440ConditionsCirrhotic Cardiomyopathy
3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Cardiac Surgery Management in Patients With Liver Cirrhosis.Reviews in cardiovascular medicine · 2026
    Review
  12. Review
  13. Fully self-gated dual-venc five-dimensional flow magnetic resonance imaging for simultaneous imaging of the cardiovascular and portal venous systems: A feasibility study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  14. [Research progress on the pathogenesis and clinical treatment of cirrhotic cardiomyopathy].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Manhal IzzyDivision of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University, Nashville, TN.ORCID 0000-0002-6402-5333
Lisa B VanWagnerDivision of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-6264-2573
Grace LinDepartment of Cardiovascular Medicine, The Mayo Clinic, Rochester, MN.
Mario AltieriDivision of Hepatology, Caen University, Caen, France.
James Y FindlayDepartment of Anesthesiology, The Mayo Clinic, Rochester, MN.
Jae K OhDepartment of Cardiovascular Medicine, The Mayo Clinic, Rochester, MN.
Kymberly D WattDivision of Gastroenterology & Hepatology, The Mayo Clinic, Rochester, MN.
Samuel S LeeLiver Unit, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Cirrhotic Cardiomyopathy Consortium

Funding

Implementation science to improve cardiovascular outcomes among liver transplant recipientsK23HL136891 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VANWAGNER, LISA B · 2017 to 2020
$757k
NHLBI NIH HHS K23 HL136891
6 · The paper itself

Abstract

Cirrhotic cardiomyopathy (CCM) is cardiac dysfunction in patients with end-stage liver disease in the absence of prior heart disease. First defined in 2005 during the World Congress of Gastroenterology, CCM criteria consisted of echocardiographic parameters to identify subclinical cardiac dysfunction in the absence of overt structural abnormalities. Significant advancements in cardiovascular imaging over the past 14 years, including the integration of myocardial deformation imaging into routine clinical practice to identify subclinical cardiovascular dysfunction, have rendered the 2005 CCM criteria obsolete. Therefore, new criteria based on contemporary cardiovascular imaging parameters are needed. In this guidance document, assembled by a group of multidisciplinary experts in the field, new core criteria based on contemporary cardiovascular imaging parameters are proposed for the assessment of CCM. This document provides a critical assessment of the diagnosis of CCM and ongoing assessment aimed at improving clinical outcomes, particularly surrounding liver transplantation. Key points and practice-based recommendations for the diagnosis of CCM are provided to offer guidance for clinicians and identify gaps in knowledge for future investigations.

Indexed as

CardiomyopathiesEnd Stage Liver DiseaseHumansLiver CirrhosisPractice Guidelines as Topic

Identifiers

PMID31342529
PMCPMC7288530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.