Evidence map›Paper›PMID 31342524›Full record

ArticleJournal of the American Geriatrics Society2019

Delirium After Transcatheter Aortic Valve Implantation Under General Anesthesia: Incidence, Predictors, and Relation to Long-Term Survival.

Kees van der Wulp, Marleen van Wely, Lars van Heijningen, Bram van Bakel, Yvonne Schoon, Michel Verkroost, Helmut Gehlmann, Leen Van Garsse, Priya Vart, Peter Kievit and 3 more

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Observational
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  19. Changes in cognitive functions and quality of life in patients after transcatheter aortic valve implantation.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kees van der WulpDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Marleen van WelyDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Lars van HeijningenDepartment of Geriatrics, Radboud University Medical Center, Nijmegen, The Netherlands.
Bram van BakelDepartment of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Yvonne SchoonDepartment of Geriatrics, Radboud University Medical Center, Nijmegen, The Netherlands.
Michel VerkroostDepartment of Cardio-Thoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Helmut GehlmannDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Leen Van GarsseDepartment of Cardio-Thoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Priya VartDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Peter KievitDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Marcel Olde RikkertDepartment of Geriatrics, Radboud University Medical Center, Nijmegen, The Netherlands.
Wim MorshuisDepartment of Cardio-Thoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Niels van RoyenDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesProspectively collected data on postoperative delirium (POD) after transcatheter aortic valve implantation (TAVI) are scarce. The aim of this study was to report the incidence and risk factors of delirium after TAVI under general anesthesia and to assess the association of POD with clinical outcome and short- and long-term survival.

designProspective cohort study.

settingAcademic medical center.

participantsA total of 703 subsequent patients undergoing TAVI under general anesthesia between 2008 and 2017. MEASUREMENTS: Delirium was assessed according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), criteria. Outcomes were postprocedural clinical outcome and short- and long-term survival (30 days and 5 years, respectively).

resultsPOD was observed in 16.5% (116/703), was the strongest independent predictor of long-term mortality (hazard ratio = 1.91; 95% confidence interval [CI] = 1.36-2.70), and was associated with impaired 30-day and 5-year survival (92.2% vs 96.8% [P = .025] and 40.0% vs 50.0% [P = .007], respectively). Stroke and new onset of atrial fibrillation were more often observed in delirious patients (6.9% vs 1.9% and 12.1% vs 5.1%, respectively). Strongest independent predictors of POD were prior delirium (odds ratio [OR] = 2.56; 95% CI = 1.52-4.31) and aortic valve area less than 0.75 cm

conclusionOne in six patients experienced POD after TAVI under general anesthesia. POD was the strongest predictor of long-term mortality and was associated with impaired short- and long-term survival. Prior delirium and a more calcified aortic valve were the strongest independent predictors of POD. J Am Geriatr Soc 67:2325-2330, 2019.

Indexed as

Postoperative ComplicationsAged, 80 and overAnesthesia, GeneralAortic Valve StenosisDeliriumFemaleFollow-Up StudiesGeriatric AssessmentHumansIncidenceMaleNetherlandsPrognosisProspective StudiesRisk AssessmentRisk Factorsgeneral anesthesiapostoperative deliriumsurvivaltranscatheter aortic valve implantation

Identifiers

PMID31342524
PMCPMC6899857

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.