Evidence map›Paper›PMID 31342346›Full record

ArticleEnvironmental science and pollution research international2019

The cytotoxic, inflammatory and oxidative potential of coconut oil-substituted diesel emissions on bronchial epithelial cells at an air-liquid interface.

Annalicia Vaughan, Svetlana Stevanovic, Andrew P W Banks, Ali Zare, Md Mostafizur Rahman, Rayleen V Bowman, Kwun M Fong, Zoran D Ristovski, Ian A Yang

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Annalicia VaughanThe University of Queensland Thoracic Research Centre, The Prince Charles Hospital, Brisbane, Australia. a.vaughan@uq.edu.au.ORCID http://orcid.org/0000-0001-5890-7877
Svetlana StevanovicInternational Laboratory for Air Quality and Health, The Queensland University of Technology, Brisbane, Australia.
Andrew P W BanksQueensland Alliance for Environmental Health Sciences, The University of Queensland, Brisbane, Australia.
Ali ZareInternational Laboratory for Air Quality and Health, The Queensland University of Technology, Brisbane, Australia.
Md Mostafizur RahmanInternational Laboratory for Air Quality and Health, The Queensland University of Technology, Brisbane, Australia.
Rayleen V BowmanThe University of Queensland Thoracic Research Centre, The Prince Charles Hospital, Brisbane, Australia.
Kwun M FongThe University of Queensland Thoracic Research Centre, The Prince Charles Hospital, Brisbane, Australia.
Zoran D RistovskiInternational Laboratory for Air Quality and Health, The Queensland University of Technology, Brisbane, Australia.
Ian A YangThe University of Queensland Thoracic Research Centre, The Prince Charles Hospital, Brisbane, Australia.
The University of Queensland · AUQueensland University of Technology · AU

Funding

Australian Research Council Discovery Grant DP120100126National Health and Medical Research Council Career Development Fellowship APP1026215Prince Albert II of Monaco Foundation (MC) NR2013-232The Prince Charles Hospital Foundation PhD Scholarship PhD2014-10
6 · The paper itself

Abstract

Diesel emissions contain high levels of particulate matter (PM) which can have a severe effect on the airways. Diesel PM can be effectively reduced with the substitution of diesel fuel with a biofuel such as vegetable oil. Unfortunately, very little is known about the cellular effects of these alternative diesel emissions on the airways. The aim of this study was to test whether coconut oil substitution in diesel fuel reduces the adverse effect of diesel emission exposure on human bronchial epithelial cells. Human bronchial epithelial cells were cultured at air-liquid interface for 7 days and exposed to diesel engine emissions from conventional diesel fuel or diesel fuel blended with raw coconut oil at low (10%), moderate (15%) and high (20%) proportions. Cell viability, inflammation, antioxidant production and xenobiotic metabolism were measured. Compared to conventional diesel, low fractional coconut oil substitution (10% and 15%) reduced inflammation and increased antioxidant expression, whereas higher fractional coconut oil (20%) reduced cell viability and increased inflammation. Therefore, cellular responses after exposure to alternative diesel emission are dependent on fuel composition.

Indexed as

BiofuelsCell SurvivalCoconut OilEpithelial CellsGasolineHumansOxidative StressParticulate MatterPlant OilsVehicle EmissionsBiofuelsCoconut OilGasolineParticulate MatterPlant OilsVehicle EmissionsAir pollutionAntioxidantsBronchial epithelial cellsCoconut oilDieselInflammationToxicity

Identifiers

PMID31342346
OpenAlexW2962945507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.