Evidence map›Paper›PMID 31342146›Full record

ReviewJournal of gastroenterology2019

Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations.

Stuart Jon Spechler

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Does Eosinophilic Esophagitis Predispose to Achalasia?Gastroenterology & hepatology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Dysmotility in Eosinophilic Esophagitis.Frontiers in pediatrics · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Stuart Jon SpechlerDivision of Gastroenterology and Center for Esophageal Diseases, Baylor University Medical Center, 3500 Gaston Avenue, 2 Hoblitzelle, Suite 250, Dallas, TX, 75246, USA. sjspechler@aol.com.ORCID http://orcid.org/0000-0001-5635-5386
Baylor University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report explores two hypotheses regarding eosinophilic esophagitis (EoE): (1) that the use of proton pump inhibitors (PPIs) might contribute to the pathogenesis of EoE by preventing peptic digestion of food allergens, by increasing gastric mucosal permeability to enable gastric absorption of those undegraded food allergens, and by causing microbial dysbiosis, and (2) that EoE, like eosinophilic gastroenteritis, might have mucosal-predominant and muscle-predominant forms, and that the muscle-predominant form of EoE might cause a variety of esophageal motility disorders including achalasia.

Indexed as

AnimalsEosinophilic EsophagitisEosinophilsEsophageal Motility DisordersFood HypersensitivityHumansProton Pump InhibitorsProton Pump InhibitorsAchalasiaEsophageal motilityProton pump inhibitors

Identifiers

PMID31342146
PMCPMC6759606
OpenAlexW2963105333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.