ReviewPediatric cardiology2019
Defects in Trabecular Development Contribute to Left Ventricular Noncompaction.
Review in Pediatric cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Cardiomyocyte-Specific bcl11b Knockout Causes Left Ventricular Noncompaction by Dysregulating pou3f2 and Titin.International journal of molecular sciences · 2026Article
- Endocardial TIE2 orchestrates cardiac trabeculation via sequestering FOXO1 within the cytoplasm and stimulating versican cleavage.Development (Cambridge, England) · 2026Article
- Left ventricular non-compaction in heart failure: contemporary perspective on diagnostic challenges and treatment opportunities.Heart failure reviews · 2026Review
- Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction.Circulation. Heart failure · 2026Article
- Suppressive Genetic Interactions Between Haploinsufficient Mitochondrial Genes Encoded in the 22q11.2 Microdeletion Locus Define Brain and Cardiac Phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Clinical characteristics and short-term outcomes of left ventricular non-compaction cardiomyopathy in neonates.Frontiers in pediatrics · 2026Article
- The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the developing heart.Communications biology · 2024Article
- Article
- CCBE1 Is Essential for Epicardial Function during Myocardium Development.International journal of molecular sciences · 2022Article
- Left ventricular noncompaction: a disorder with genotypic and phenotypic heterogeneity-a narrative review.Cardiovascular diagnosis and therapy · 2022Review
- PKN2 deficiency leads both to prenatal 'congenital' cardiomyopathy and defective angiotensin II stress responses.The Biochemical journal · 2022Article
- Left Ventricular Noncompaction Is Associated with Valvular Regurgitation and a Variety of Arrhythmias.Journal of cardiovascular development and disease · 2022Article
- New Insights into the Development and Morphogenesis of the Cardiac Purkinje Fiber Network: Linking Architecture and Function.Journal of cardiovascular development and disease · 2021Review
- An eIF3a gene mutation dysregulates myocardium growth with left ventricular noncompaction via the p-ERK1/2 pathway.Genes & diseases · 2021Article
- Noncompaction Cardiomyopathy-History and Current Knowledge for Clinical Practice.Journal of clinical medicine · 2021Review
- Response to the letter to the editor: unravel the genetic background of noncompaction before relating it with myocardial hypoperfusion.ESC heart failure · 2020Article
- Case Report: Sudden cardiac death due to ventricular myocardial non-compaction.F1000Research · 2020Article
- Left Ventricle Noncompaction Phenotype: Cause or Consequence?Journal of cardiovascular echographyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Left ventricular noncompaction (LVNC) is a genetically heterogeneous disorder the etiology of which is still debated. During fetal development, trabecular cardiomyocytes contribute extensively to the working myocardium and the ventricular conduction system. The impact of developmental defects in trabecular myocardium in the etiology of LVNC has been debated. Recently we generated new mouse models of LVNC by the conditional deletion of the key cardiac transcription factor encoding gene Nkx2-5 in trabecular myocardium at critical steps of trabecular development. These conditional mutant mice recapitulate pathological features similar to those observed in LVNC patients, including a hypertrabeculated left ventricle with deep endocardial recesses, subendocardial fibrosis, conduction defects, strain defects, and progressive heart failure. After discussing recent findings describing the respective contribution of trabecular and compact myocardium during ventricular morphogenesis, this review will focus on new data reflecting the link between trabecular development and LVNC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.