ArticleClinical and translational radiation oncology2019
Adaptive radiotherapy: The Elekta Unity MR-linac concept.
Article in Clinical and translational radiation oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06244537 (Study on the Safety and Efficacy of MR-Linac Technique in Patients With Unresectable Locally Advanced Colon Cancer), which is not on this map. Cited by 338 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Safety and Efficacy of MR-Linac Technique in Patients With Unresectable Locally Advanced Colon Cancer
Who cites it
338 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Failure modes and effects analysis for clinical implementation of online adaptive radiotherapy: A systematic review.Journal of applied clinical medical physics · 2026Pooled it
- Joint EANM-SNMMI guideline on the role of 2-[European journal of nuclear medicine and molecular imaging · 2024Guideline
- Magnetic resonance-guided simultaneous multi-focal adaptive radiotherapy for prostate, pElvis & metastases (MRgSMART-PEM) in prostate cancer: a prospective phase II study.Radiation oncology (London, England) · 2026Trial
- Daily adaptive 1.5 T MR-Linac image-guided re-irradiation for prostate cancer: an international retrospective experience.Clinical and translational radiation oncology · 2027Article
- Simultaneous T1, T2, R2*, PDFF, and triglyceride quantification in the head and neck using magnetic resonance fingerprinting on a 1.5T MR-Linac.Medical physics · 2026Article
- Evaluation of online dose-guided adaptive fractionation for intact prostate radiotherapy.Journal of applied clinical medical physics · 2026Article
- MR-Guided Adaptive Radiotherapy in Lung Cancer: Current Landscape and Future Directions.Cancers · 2026Review
- Evaluation of AI-based segmentation and synthetic CT generation for MRI-only prostate radiotherapy planning.Journal of applied clinical medical physics · 2026Article
- Automated planning architectures for online adaptive radiotherapy: A narrative review of the ethos and unity/Monaco platforms.Journal of applied clinical medical physics · 2026Review
- Automated workflow for target volume propagation in online adaptive magnetic resonance guided radiotherapy for lung lesions using foundation models.Physics and imaging in radiation oncology · 2026Article
- Image-based evaluation of a commercial AI synthetic CT generator for brain and prostate MR-only radiotherapy.Journal of applied clinical medical physics · 2026Article
- Transition from Oncologist- to Therapist-Led MRI-Guided Ultra-Hypofractionated Adaptive Prostate Radiation Therapy: Evaluation of Early Clinical Outcomes.Current oncology (Toronto, Ont.) · 2026Article
- Real-time motion tracking of a gold implant in water by Cherenkov lights.Journal of applied clinical medical physics · 2026Article
- FS-Mamba: Feature-wise scanning Mamba UNet for automatic image segmentation in liver tumor radiotherapy.Journal of applied clinical medical physics · 2026Article
- Development of a cost-effective end-to-end commissioning test for simulation-omitted direct-to-unit adaptive radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Evaluation of ThinkQA (v2.0.1.11) as an online secondary dose check for MR guided radiation therapy with the Elekta Unity MR-Linac.Physical and engineering sciences in medicine · 2026Article
- Optimal timing of the cumulative dose and factors related to acute urinary toxicity in prostate cancer treated using magnetic resonance linear accelerator.Radiological physics and technology · 2026Article
- Improving workflow efficiency during prostate stereotactic body radiotherapy using real-time adaptive planning associated with reduced intra-fractional target motion.Radiation oncology (London, England) · 2026Article
- Journey through technological advancements in radiation therapy.World journal of radiology · 2026Review
- Comparison of gantry-less magnetic resonance guided proton therapy with photon therapy for hepatocellular carcinoma patients.Physics and imaging in radiation oncology · 2026Article
278 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe promise of the MR-linac is that one can visualize all anatomical changes during the course of radiotherapy and hence adapt the treatment plan in order to always have the optimal treatment. Yet, there is a trade-off to be made between the time spent for adapting the treatment plan against the dosimetric gain. In this work, the various daily plan adaptation methods will be presented and applied on a variety of tumour sites. The aim is to provide an insight in the behavior of the state-of-the-art 1.5 T MRI guided on-line adaptive radiotherapy methods. MATERIALS AND
methodsTo explore the different available plan adaptation workflows and methods, we have simulated online plan adaptation for five cases with varying levels of inter-fraction motion, regions of interest and target sizes: prostate, rectum, esophagus and lymph node oligometastases (single and multiple target). The plans were evaluated based on the clinical dose constraints and the optimization time was measured.
resultsThe time needed for plan adaptation ranged between 17 and 485 s. More advanced plan adaptation methods generally resulted in more plans that met the clinical dose criteria. Violations were often caused by insufficient PTV coverage or, for the multiple lymph node case, a too high dose to OAR in the vicinity of the PTV. With full online replanning it was possible to create plans that met all clinical dose constraints for all cases.
conclusionDaily full online replanning is the most robust adaptive planning method for Unity. It is feasible for specific sites in clinically acceptable times. Faster methods are available, but before applying these, the specific use cases should be explored dosimetrically.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.