ArticleClinical and translational radiation oncology2019
Chronic radiation-associated dysphagia in oropharyngeal cancer survivors: Towards age-adjusted dose constraints for deglutitive muscles.
Article in Clinical and translational radiation oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients.The Cochrane database of systematic reviews · 2025Pooled it
- Risk prediction models for dysphagia after radiotherapy among patients with head and neck cancer: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- Machine Learning for Head and Neck Cancer: A Safe Bet?-A Clinically Oriented Systematic Review for the Radiation Oncologist.Frontiers in oncology · 2021Pooled it
- Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia.International journal of radiation oncology, biology, physics · 2021Trial
- Trial
- Improving Survival Prediction of Head and Neck Cancer Patients by Modeling Long-term Symptom Burden.Proceedings. IEEE International Conference on Healthcare Informatics · 2026Article
- FlavorCharter: Development of a Smartphone App for Quantifying Food Flavor.Proceedings ... ICDM workshops. IEEE International Conference on Data Mining · 2025Article
- PRO-Based Stratification Improves Model Prediction for Toxicity and Survival of Head and Neck Cancer Patients.IEEE journal of biomedical and health informatics · 2025Article
- Characterizing Physiologic Swallowing Impairment Profiles: A Large-Scale Exploratory Study of Head and Neck Cancer, Stroke, Chronic Obstructive Pulmonary Disease, Dementia, and Parkinson's Disease.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Roses Have Thorns: Understanding the Downside of Oncological Care Delivery Through Visual Analytics and Sequential Rule Mining.IEEE transactions on visualization and computer graphics · 2024Article
- Spatially-aware clustering improves AJCC-8 risk stratification performance in oropharyngeal carcinomas.Oral oncology · 2023Article
- Improving Prediction of Late Symptoms using LSTM and Patient-reported Outcomes for Head and Neck Cancer Patients.Proceedings. IEEE International Conference on Healthcare Informatics · 2023Article
- Surgical Treatment for Advanced Oropharyngeal Cancer: A Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- Article
- The Relationships Between Radiation Dosage and Long-term Swallowing Kinematics and Timing in Nasopharyngeal Carcinoma Survivors.Dysphagia · 2022Article
- THALIS: Human-Machine Analysis of Longitudinal Symptoms in Cancer Therapy.IEEE transactions on visualization and computer graphics · 2022Article
- Enteral tube feeding of head and neck cancer patients undergoing definitive chemoradiotherapy in the Nordic Countries: Survey of the Scandinavian Society for Head and Neck Oncology.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Precision association of lymphatic disease spread with radiation-associated toxicity in oropharyngeal squamous carcinomas.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Article
- Predicting late symptoms of head and neck cancer treatment using LSTM and patient reported outcomes.Proceedings. International Database Engineering and Applications Symposium · 2021Article
- Identifying Symptom Clusters Through Association Rule Mining.Artificial intelligence in medicine. Conference on Artificial Intelligence in Medicine (2005- ) · 2021Article
Corrections and comments
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Authors and funding
2 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesWe sought to model chronic radiation-associated dysphagia (RAD) in patients given intensity-modulated radiation therapy (IMRT) for oropharyngeal squamous cell cancer (OPSCC) as a function of age and dose to non-target swallowing muscles.
methodsWe reviewed 300 patients with T1-T4 N0-3 M0 OPSCC given definitive IMRT with concurrent chemotherapy. Chronic RAD was defined as aspiration or stricture on videoflouroscopy/endoscopy, gastrostomy tube, or aspiration pneumonia at ≥12 months after IMRT. Doses to autosegmented regions of interest (ROIs; inferior, middle and superior constrictors, anterior and posterior digastrics, mylo/geniohyoid complex, intrinsic tongue, and gengioglossus) were obtained from DICOM-RT plans and dose-volume histograms. The probability of chronic RAD as a function of mean ROI dose, stratified by age (<50, 50-59, 60-69, or ≥70 years), was estimated with logistic probability models and subsequent unsupervised nonlinear curves.
resultsChronic RAD was observed in 34 patients (11%). Age was a significant correlate of chronic RAD, both independently and with dose for all muscle groups examined. Distinct muscle-specific dose-response profiles were observed as a function of age (e.g., 5% of patients in their 50 s [but 20% of those 70 + ] who received 60 Gy to the superior constrictor had chronic RAD). This effect was stable across all observed muscle ROIs, with a false discovery rate-corrected
conclusionsAge at treatment moderates the probability of chronic RAD after chemo-IMRT for OPSCC, with aging muscles showing lower dose thresholds. Uniform dose constraints may not predict toxicity in older patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.