ArticleAnesthesiology and pain medicine2019
Comparison of the Sedation Quality of Etomidate, Propofol, and Midazolam in Combination with Fentanyl During Phacoemulsification Cataract Surgery: A Double-Blind, Randomized, Controlled, Clinical Trial.
Article in Anesthesiology and pain medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Trial
- Efficacy of a premedication with melatonin during cataract surgery under peribulbar block: a prospective randomized double-blinded study.La Tunisie medicaleTrial
- Article
- Comparison of the Cardiovascular Response to Sedation with Dexmedetomidine, Midazolam, and Etomidate in Phacoemulsification under Local Topical Anesthesia; A Double-Blind Randomized Controlled Clinical Trial.Advanced biomedical research · 2024Article
- Successful Use of Low-Dose Combination Propofol and Fentanyl in Cataract Surgery Phacoemulsification.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Propofol's Efficacy and Outcomes on Anxious Children's Behavior in the Course of Dental Therapy: An Interventional Trial.Journal of pharmacy & bioallied sciences · 2022Article
- Persistent opioid use in cataract surgery pain management and the role of nonopioid alternatives.Journal of cataract and refractive surgery · 2022Article
- Evaluating the preventive effect of metoclopramide and aminophylline on pain after deep vitrectomy.International journal of physiology, pathophysiology and pharmacology · 2022Article
- A Comparative Study of the Effect of Anesthesia Induction with the Use of Four Drug Combinations Including "Propofol," "Etomidate-Propofol," "Thiopental," and "Midazolam-Thiopental" on Hemodynamic Changes during the Insertion of Laryngeal Mask in Eye Surgery.Advanced biomedical research · 2022Article
- Vitreoretinal Surgery Under Sub-Tenon's Block and Conscious Sedation in a Patient with Brugada Syndrome: A Case Report and Literature Review.Anesthesiology and pain medicine · 2021Article
- Practical Considerations for Dexmedetomidine Sedation in Adult Cataract Surgery Under Local/Regional Anesthesia: A Narrative Review.Anesthesiology and pain medicine · 2021Review
- Perioperative Anxiolytic and Analgesic Effects of Pregabalin in Vitreo-Retinal Surgery: A Randomized, Double-blind Study.Anesthesiology and pain medicine · 2021Article
- A Comparative Study of Valsalva Maneuver, Lidocaine, and Valsalva Maneuvers with Administration of Lidocaine to Reduce the Pain Associated with Administration of Etomidate During General Anesthesia.Anesthesiology and pain medicine · 2021Article
- Anesthesia Considerations for Cataract Surgery in Patients with Schizophrenia: A Narrative Review.Anesthesiology and pain medicine · 2021Review
- Effect of Benson's Relaxation Technique on Propofol Consumption and Preoperative Anxiety of Patients Undergoing Cataract Surgery.Anesthesiology and pain medicine · 2020Article
- Comparison of the Sedative, Hemodynamic, and Anesthetic Effect of Dexmedetomidine, Ketamine, and Etomidate on Cataract Surgery by Phacoemulsification Method: A Randomized Clinical Trial.Journal of current ophthalmologyArticle
- Comparing benzodiazepine-ketamine and benzodiazepine-fentanyl sedation in phacoemulsification: A double-blind crossover non-inferiority clinical trial (BEKEF study).Advances in ophthalmology practice and researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccording to the favorable effects of combination therapy to provide better sedation during phacoemulsification and lack of any studies investigating the sedative effect of etomidate, propofol, and midazolam in combination with fentanyl during the procedure.
objectivesThe current study aimed at comparing the sedative properties of the mentioned three combination therapies in this field.
methodsThe current double-blind, randomized, controlled clinical trial was conducted on patients referred for elective phacoemulsification surgery under sedation. They were randomly allocated to the three groups to receive fentanyl plus one of the following medications: Propofol, midazolam, and etomidate. Demographic characteristics, medical condition, and hemodynamic parameters before, during, and after surgery, sedation level, anesthetic complications, sedation-related adverse events, and patients' and surgeons' satisfaction were evaluated and recorded by the anesthesiologist and compared in the three studied groups.
resultsIn the current study, out of 150 enrolled patients, 98 completed the study. Frequency of different levels of Ramsay scores was not significantly different between the groups (P = 0.41). Frequency of Ramsay scores 3 and 4 was 92%, 79.4%, and 88.2% in etomidate, midazolam and propofol groups, respectively (P = 0.32). The median recovery time was significantly higher in the midazolam group than the propofol group (P = 0.04); intergroup comparisons indicated that the patients' mean score of satisfaction in the propofol group was significantly higher than that of the etomidate group (P = 0.006).
conclusionsThe current study findings indicated that though the quality of sedation during phacoemulsification cataract surgery was acceptable in the three agents and the results had no significantly differences among the groups, and considering other factors including recovery time, hemodynamic evaluation, sedation-related complications, and patients' satisfication scores, it is suggested that propofol was superior to the other two agents.
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