Evidence map›Paper›PMID 31341687›Full record

ArticleCase reports in oncological medicine2019

Combined Hepatocholangiocarcinoma Associated with Humoral Hypercalcemia of Malignancy and Chronic Inflammatory Demyelinating Polyneuropathy.

Ruben Manuel Luciano Colunga Biancatelli, Marco Ciacciarelli, Alessandro Polidoro, Piera Clemenzi, Viviana Congedo, Leonardo Calvosa, Eleonora D'Armiento, Carmen Misurale, Davide Bellini, Stefano Badia and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ruben Manuel Luciano Colunga BiancatelliDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Marco CiacciarelliDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.ORCID https://orcid.org/0000-0001-7523-0191
Alessandro PolidoroDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Piera ClemenziDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Viviana CongedoDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Leonardo CalvosaDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Eleonora D'ArmientoDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Carmen MisuraleDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Davide BelliniDepartment of Radiological Sciences, Oncology and Pathology, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Stefano BadiaDepartment of Radiological Sciences, Oncology and Pathology, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Massimiliano ManciniDepartment of Medico-Surgical Sciences and Biotechnologies, Pathology Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Vincenzo PetrozzaDepartment of Medico-Surgical Sciences and Biotechnologies, Pathology Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.
Luigi IulianoDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, "Sapienza" University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy.ORCID https://orcid.org/0000-0002-0027-9326

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraneoplastic syndromes are often a diagnostic challenge to doctors and may have a heterogeneous presentation, including humoral hypercalcemia of malignancy (HHM), most commonly caused by squamous cell cancer and renal, ovarian, endometrial, and breast cancer. Chronic inflammatory demyelinating polyneuropathy (CIDP) has been described in patients affected by several types of cancer, especially hematologic malignancies, and a possible paraneoplastic pathogenesis of this neurological disease has been suggested. This report describes a 56-year-old man with a history of CIDP diagnosed 3 months earlier and persistently elevated aminotransferases for 18 months who was admitted to our internal medicine unit with abdominal pain, fatigue, and severe hypercalcemia with low serum intact parathyroid hormone. Parathyroid hormone-related protein (PTH-rP) was markedly high. Liver imaging showed a large hepatic mass in the right lobe, and percutaneous ultrasound-guided biopsy revealed histopathological findings consistent with a combined hepatocholangiocarcinoma (CHCC). We supposed that both HHM and CIDP could represent a paraneoplastic manifestation of CHCC.

Identifiers

PMID31341687
PMCPMC6612990

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