ReviewJournal of ophthalmology2019
Pain Perception of the First Eye versus the Second Eye during Phacoemulsification under Local Anesthesia for Patients Going through Cataract Surgery: A Systematic Review and Meta-Analysis.
Review in Journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Topical and subconjunctival anesthesia versus topical anesthesia alone in patients with senile cataracts undergoing phacoemulsification: a double-blind randomized controlled trial.BMC ophthalmology · 2024Trial
- A double-blinded randomized clinical trial for pain perception: The efficacy and safety of topical cold saline solution anesthesia in phacoemulsification.Indian journal of ophthalmology · 2022Trial
- Substance P induces sympathetic immune response in the contralateral eye after the first eye cataract surgery in type 2 diabetic patients.BMC ophthalmology · 2020Trial
- Effect of Gabapentin Pretreatment on Hyperalgesia in Older Patients Undergoing Sequential Bilateral Cataract Surgery: A Prospective, Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Postoperative Inflammation and Pain Management with Intracanalicular Dexamethasone Insert: Real-World Applications.Ophthalmology and therapy · 2026Review
- Evaluation of Routine Clinical Deployment of an Autonomous Artificial Intelligence Assistant for Cataract Follow-Up in the National Health Service.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye.BMJ open ophthalmology · 2025Observational
- Changes in aqueous humor cytokines and metabolomics in contralateral eye after unilateral cataract surgery.BMC ophthalmology · 2025Article
- Systemic inflammatory and oxidative stress biomarkers as predictors of pain in sequential bilateral phacoemulsification for age-related cataract.Frontiers in medicine · 2025Article
- Second Eye Syndrome: Patients' Perspectives Regarding First Eye versus Second Eye Phacoemulsification and Intraocular Lens Implantation Surgery.Patient preference and adherence · 2025Article
- Comparative visual outcomes of the first versus second eye following small-incision lenticule extraction (SMILE).BMC ophthalmology · 2024Article
- Preoperative anxiety and postoperative pain associated with cataract surgery under local anesthesia.La Tunisie medicale · 2024Article
- Safety and feasibility of sutureless pars-plana vitrectomy in sub-Tenon anesthesia (SAFE-VISA): a prospective study.European journal of medical research · 2023Article
- Comparison of Pain between First and Second Operated Eyelids after Upper Eyelid Blepharoplasty.Korean journal of ophthalmology : KJO · 2023Observational
- Effects of Low-Concentration Nitrous Oxide Anesthesia on Patient Anxiety During Cataract Surgery: A Retrospective Cohort Study.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Comparison of auditory sensations in patients who underwent cataract phacoemulsification surgery in the first and second eye.Scientific reports · 2021Observational
- Dynamic monocyte chemoattractant protein-1 level as predictors of perceived pain during first and second phacoemulsification eye surgeries in patients with bilateral cataract.BMC ophthalmology · 2021Article
- Subjective Opinions of Patients About Step-by-Step Cataract Surgery Preparation.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Use of Simultaneous Bilateral Cataract Surgery (SBCS) to Optimize Parameters Affecting the Subjective Perception of the Procedure.Journal of ophthalmology · 2021Article
- Correlation between Hyperalgesia and Upregulation of TNF-Journal of immunology research · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhacoemulsification under local anesthesia is regarded as the major surgery for cataract treatment. Recent research has compared the pain perception between the first eye and the second eye during phacoemulsification. However, these studies have also yielded controversial findings. Consequently, we performed a systematic review and a meta-analysis to investigate the difference in the pain perception between the first and second eyes during phacoemulsification.
methodWe searched the PubMed, EMBASE, and Cochrane CENTRAL databases for the studies published up to October 5, 2018. Prospective observational studies were included. The meta-analysis was conducted by means of random-effects model and fixed-effects model according to the heterogeneity. Evaluation of the methodological quality of studies was based on Newcastle-Ottawa Scale (NOS).
resultsOverall, eight studies were included in the meta-analysis. The analysis of pooled data showed that the pain scores of the first eye shortly after surgery under local anesthesia were significantly lower as compared to the second eye (WMD: 0.69; 95% CI: 0.40, 0.98;
conclusionPatients experienced more pain in the surgery of the second eye than that of the first eye, which probably related to lower anxiety before the second surgery. It suggests that we should consider preoperative intervention to reduce the perceived pain during second eye cataract surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.