ArticleToxicological research2019
Gestational Exposure to Pesticides Induces Oxidative Stress and Lipid Peroxidation in Offspring that Persist at Adult Age in an Animal Model.
Article in Toxicological research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Sex-Specific sRNA Signatures in Rat Liver Reveal Divergent Alterations Following Perinatal Exposure to Glyphosate and Its Mixture with 2,4-D and Dicamba.International journal of molecular sciences · 2026Article
- Biochemical Responses of Anopheles spp. Larvae to a Novel Brazilian BR101 Bacillus thuringiensis var. israelensis Formulation: Oxidative Stress, Detoxification Enzymes, and Safety for Nontarget Notonectidae and Gerridae Aquatic Insects.Chemistry & biodiversity · 2026Article
- Designing Trifluoromethyl Pyrazolones for Selective Molluscicidal Activity AgainstJournal of agricultural and food chemistry · 2025Article
- Impact of lufenuron on hematology, serum biochemistry, antioxidant enzymes, and histopathology in broiler chickens.PloS one · 2025Article
- Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies.Journal of health & pollution · 2024Review
- Article
- The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis.International journal of molecular sciences · 2024Review
- Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice.Antioxidants (Basel, Switzerland) · 2023Article
- Reproductive effects of sulfoxaflor in male Sprague Dawley rats.Environmental science and pollution research international · 2022Article
- Commentary: Novel strategies and new tools to curtail the health effects of pesticides.Environmental health : a global access science source · 2021Article
- Conserved Metabolic and Evolutionary Themes in Microbial Degradation of Carbamate Pesticides.Frontiers in microbiology · 2021Review
- Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses.Scientific reports · 2020Article
- Metabolic effects of exposure to pesticides during gestation in female Wistar rats and their offspring: a risk factor for diabetes?Toxicological research · 2020Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pesticide exposure may induce biochemical alterations including oxidative stress and lipid peroxidation. However, in the context of developmental origin of health and disease, putative trans-generational effect of exposure to pesticides are insufficiently studied. We therefore aimed to evaluate the biochemical effect of gestational exposure to four pesticides on female Wistar rats and their offspring at adult age. We studied 30 female nulliparous Wistar rats divided into 5 equal groups. Group 1 served as the control group and received distilled water while group 2, 3, 4 and 5 received orally pesticide 1 (imidacloprid), pesticide 2 (chlorpyrifos), pesticide 3 (imidacloprid + lambda cyhalothrin) and pesticide 4 (oxamyl) respectively once daily throughout gestation at a dose equivalent to 1/10 lethal dose 50. The mothers were followed up until one month post gestation. The offspring were followed up from birth until adult age (12 weeks). In all animals at each time point we evaluated malondialdehyde (MDA), oxidative stress and liver function enzymes. There was similar variation of total body weight in all the groups during and after gestation. However, Female Wistar rats of the exposed groups had significant alterations in liver SOD (-30.8% to +64.1%), catalase (-38.8% to -85.7%) and GSH (-29.2% to -86.5%) and; kidney catalase (> 100%), GSH (> 100%). Moreover, MDA, alanine transaminase (ALT) and aspartate transaminase (AST) levels were significantly higher in pesticide exposed rats compared to the control group. Similar alterations in antioxidant enzymes, MDA and liver function enzymes were observed in offspring of treated rats evidenced at weaning and persisting until adult age. Exposure to pesticides causes oxidative stress and lipid peroxidation in exposed female Wistar rats and their offspring. The persistence in offspring at adult age suggests transgenerational adverse effects.
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