Evidence map›Paper›PMID 31341414›Full record

ArticleInternational journal of medical sciences2019

Synthesis and Evaluation of BMMSC-seeded BMP-6/nHAG/GMS Scaffolds for Bone Regeneration.

Xuewen Li, Ran Zhang, Xuexin Tan, Bo Li, Yao Liu, Xukai Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Stem Cells and Bone Tissue Engineering.Life (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xuewen LiDepartment of Oral Anatomy and Physiology, School of Stomatology, China Medical University, Shenyang, China.
Ran ZhangDepartment of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China.
Xuexin TanDepartment of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China.
Bo LiDepartment of Oral Anatomy and Physiology, School of Stomatology, China Medical University, Shenyang, China.
Yao LiuDepartment of Pediatric Dentistry, School of Stomatology, China Medical University, Shenyang, China.
Xukai WangDepartment of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioactive scaffolding materials and efficient osteoinductive factors are key factors for bone tissue engineering. The present study aimed to mimic the natural bone repair process using an osteoinductive bone morphogenetic protein (BMP)-6-loaded nano-hydroxyapatite (nHA)/gelatin (Gel)/gelatin microsphere (GMS) scaffold pre-seeded with bone marrow mesenchymal stem cells (BMMSCs). BMP-6-loaded GMSs were prepared by cross-linking and BMP-6/nHAG/GMS scaffolds were fabricated by a combination of blending and freeze-drying techniques. Scanning electron microscopy, confocal laser scanning microscopy, and CCK-8 assays were carried out to determine the biocompatibility of the composite scaffolds

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsBone Morphogenetic Protein 6Bone RegenerationCell DifferentiationCell SurvivalDisease Models, AnimalDrug CarriersDrug CompoundingDurapatiteFractures, BoneFreeze DryingGelatinHumansMaleMaterials TestingBMP6 protein, humanBone Morphogenetic Protein 6Drug CarriersDurapatiteGelatinbone marrow mesenchymal stem cellsbone morphogenetic protein-6bone tissue engineeringOsteoconductive scaffold

Identifiers

PMID31341414
PMCPMC6643122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.