Evidence map›Paper›PMID 31341377›Full record

ArticleComplexity2019

Analyzing Knowledge Retrieval Impairments Associated with Alzheimer's Disease Using Network Analyses.

Jeffrey C Zemla, Joseph L Austerweil

Abstract read
In one paragraph

Article in Complexity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  7. Review
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  13. SNAFU: The Semantic Network and Fluency Utility.Behavior research methods · 2020
    Article
  14. Article
  15. Article
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jeffrey C ZemlaDepartment of Psychology, University of Wisconsin-Madison, USA.ORCID 0000-0001-7334-4961
Joseph L AusterweilDepartment of Psychology, University of Wisconsin-Madison, USA.ORCID 0000-0002-1316-4691

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
Research Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6M
Computational modeling of semantic decline in Alzheimer's diseaseR21AG053467 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AUSTERWEIL, JOSEPH LARRY, ZEMLA, JEFFREY C · 2016 to 2017
$400k
NIA NIH HHS P50 AG005131NIA NIH HHS R21 AG053467NLM NIH HHS T15 LM007359
6 · The paper itself

Abstract

A defining characteristic of Alzheimer's disease is difficulty in retrieving semantic memories, or memories encoding facts and knowledge. While it has been suggested that this impairment is caused by a degradation of the semantic store, the precise ways in which the semantic store is degraded are not well understood. Using a longitudinal corpus of semantic fluency data (listing of items in a category), we derive semantic network representations of patients with Alzheimer's disease and of healthy controls. We contrast our network-based approach with analyzing fluency data with the standard method of counting the total number of items and perseverations in fluency data. We find that the networks of Alzheimer's patients are more connected and that those connections are more randomly distributed than the connections in networks of healthy individuals. These results suggest that the semantic memory impairment of Alzheimer's patients can be modeled through the inclusion of spurious associations between unrelated concepts in the semantic store. We also find that information from our network analysis of fluency data improves prediction of patient diagnosis compared to traditional measures of the semantic fluency task.

Identifiers

PMID31341377
PMCPMC6656530

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.