ArticleThe Journal of physical chemistry1991
End-to-End Diffusion and Distance Distributions of Flexible Donor-Acceptor Systems Observed by Intramolecular Energy Transfer and Frequency-Domain Fluorometry; Enhanced Resolution by Global Analysis of Externally Quenched and Nonquenched Samples.
Article in The Journal of physical chemistry, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Two Orders of Magnitude Variation of Diffusion-Enhanced Förster Resonance Energy Transfer in Polypeptide Chains.Polymers · 2018Article
- Effect of Diffusion on Resonance Energy Transfer Rate Distributions: Implications for Distance Measurements.The journal of physical chemistry. B · 2015Article
- End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Fluorescence study of neurohypophyseal hormones and their analogues. Distance distributions in a series of arginine-vasopressin analogues.European biophysics journal : EBJ · 1997Article
- Resolution of multiexponential spectral relaxation of Yt-base by global analysis of collisionally quenched samples.Journal of fluorescence · 1996Article
- End-to-end diffusion coefficients and distance distributions from fluorescence energy transfer measurements: Enhanced resolution by using multiple donors with different lifetimes.Journal of fluorescence · 1995Article
- Fluorescence study of conformational flexibility of RNase S-peptide: distance-distribution, end-to-end diffusion, and anisotropy decays.Biochemistry · 1993Article
- Time-resolved energy transfer measurements of donor-acceptor distance distributions and intramolecular flexibility of a CCHH zinc finger peptide.Biochemistry · 1993Article
- Distance distributions and dynamics of a zinc finger peptide from fluorescence resonance energy transfer measurements.Journal of fluorescence · 1993Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We used time-dependent fluorescence energy transfer of externally quenched and nonquenched samples, and global analysis of the data, to recover the end-to-end distance distributions and diffusion coefficients of flexible fluorescent molecules in low-viscosity solution. The fluorescence decays of tryptamine covalently linked to a dansyl acceptor by a polyethylene chain of 22 methylene groups were measured by the frequency-domain method. The data were fitted using numerical solutions of the diffusion equation which predicts the time- and distance-dependent population of the excited-state donors in the presence of energy transfer, followed by transformation to the frequency domain for nonlinear least-squares fitting to the experimental data. From the simulation study we found that the time- and distance-dependent population of the excited-state donors are significantly different for nonquenched and quenched samples and that the effects of end-to-end diffusion on the donor decay is decreased by collisional quenching. Importantly, the resolution is dramatically improved by the use of simultaneous analysis of quenched and nonquenched samples. This method was applied to the tryptamine-dansyl system using acrylamide as an external quencher. The recovered initial (
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