Evidence map›Paper›PMID 31341302›Full record

ReviewNature2019

Advances in epigenetics link genetics to the environment and disease.

Giacomo Cavalli, Edith Heard

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 767 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
767citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

767 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  13. Magnesium Attenuates Renal Senescence and Fibrosis With Reduced DNA Damage Response and H3K4me3 Enrichment at the p16FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  20. Genome-wide chromatin recording resolves dynamic cell state changes.bioRxiv : the preprint server for biology · 2026
    Article

707 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Giacomo CavalliInstitute of Human Genetics, CNRS and University of Montpellier, Montpellier, France. giacomo.cavalli@igh.cnrs.fr.
Edith HeardEuropean Molecular Biology Laboratory (EMBL), Heidelberg, Germany. edith.heard@embl.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified excitement and hope, but also a degree of hype. Here we review how the field has evolved over the last few decades and reflect on some of the recent advances that are changing our understanding of biology. We discuss the interplay between epigenetics and DNA sequence variation as well as the implications of epigenetics for cellular memory and plasticity. We consider the effects of the environment and both intergenerational and transgenerational epigenetic inheritance on biology, disease and evolution. Finally, we present some new frontiers in epigenetics with implications for human health.

Indexed as

Gene-Environment InteractionAgingAnimalsChromatinDiseaseDNA MethylationEpigenesis, GeneticEpigenomicsGenetic VariationHumansNeoplasmsChromatin

Identifiers

PMID31341302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.