ArticleNature2019
Flower isoforms promote competitive growth in cancer.
Abstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 148 citations in OpenAlex.
- Flower Delivery: The Emergence of FLOWER (FWE) as a Multifunctional Regulator of Endo-Lysosome-Related Organelle Trafficking Across Cell Types.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells.Nature communications · 2026Article
- Streptomyces produce a diphtheria toxin-like exotoxin that targets insects.Nature microbiology · 2026Article
- The human Flower isoform hFWE4 facilitates cornification in cutaneous squamous cell carcinoma.JID innovations : skin science from molecules to population health · 2026Article
- Development of a highly differentiated rat brain organoid model for exploring glioblastoma invasion dynamics and therapy.Neuro-oncology · 2026Article
- Imaging Cell Competition in Ex-VivoMethods and protocols · 2025Article
- Dietary Interventions Modulate Cell Competition and Locomotor Decline in an Alzheimer's DiseaseCells · 2025Article
- Cell Death, Compensatory Proliferation, and Cell Competition.Annual review of genetics · 2025Review
- Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells.Nature biotechnology · 2025Article
- Multi-scale and multi-context interpretable mapping of cell states across heterogeneous spatial samples.Nature communications · 2025Article
- X-linked competition - implications for human development and disease.Nature reviews. Genetics · 2025Review
- Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier.Nature communications · 2025Article
- Sensing of extracellular l-proline availability by the integrated stress response determines the outcome of cell competition.Science advances · 2025Article
- SC2Spa: a deep learning based approach to map transcriptome to spatial origins at cellular resolution.BMC bioinformatics · 2025Article
- Article
- Anti-Tumour Immunity Relies on Targeting Tissue Homeostasis Through Monocyte-Driven Responses Rather Than Direct Tumour Cytotoxicity.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- The end of the genetic paradigm of cancer.PLoS biology · 2025Review
- Genetic and Epigenetic Intersections in COVID-19-Associated Cardiovascular Disease: Emerging Insights and Future Directions.Biomedicines · 2025Review
- Messages from Beyond the Grave: How Can Drosophila Help Us Understand the Consequences of Apoptosis?Advances in experimental medicine and biology · 2025Review
- Neuromorphic algorithms for brain implants: a review.Frontiers in neuroscience · 2025Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
27 authors at 10 institutions in 4 countries.
Esha MadanChampalimaud Centre for the Unknown, Lisbon, Portugal.
Christopher J Pelham *Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Masaki Nagane *Department of Biochemistry, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Taylor M Parker *Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Rita Canas-MarquesChampalimaud Centre for the Unknown, Lisbon, Portugal.
Kimberly FazioDepartment of Biomedical Sciences, Creighton University, Omaha, NE, USA.
Kranti ShaikDepartment of Biomedical Sciences, Creighton University, Omaha, NE, USA.
Youzhong YuanDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Vanessa HenriquesChampalimaud Centre for the Unknown, Lisbon, Portugal.
Antonio GalzeranoChampalimaud Centre for the Unknown, Lisbon, Portugal.
Tadashi YamashitaDepartment of Biochemistry, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Miguel Alexandre Ferreira PintoChampalimaud Centre for the Unknown, Lisbon, Portugal.
Antonio M PalmaChampalimaud Centre for the Unknown, Lisbon, Portugal.
Denise CamachoChampalimaud Centre for the Unknown, Lisbon, Portugal.
Ana VieiraChampalimaud Centre for the Unknown, Lisbon, Portugal.
David SoldiniInstitute for Surgical Pathology, University Hospital and University of Zurich, Zurich, Switzerland.
Harikrishna NakshatriDepartment of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Steven R PostDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Christa RhinerChampalimaud Centre for the Unknown, Lisbon, Portugal.
Hiroko YamashitaDepartment of Breast Surgery, Hokkaido University Hospital, Sapporo, Japan.
Davide AccardiChampalimaud Centre for the Unknown, Lisbon, Portugal.
Laura A HansenDepartment of Biomedical Sciences, Creighton University, Omaha, NE, USA.
Carlos CarvalhoChampalimaud Centre for the Unknown, Lisbon, Portugal.
Antonio L BeltranChampalimaud Centre for the Unknown, Lisbon, Portugal.
Periannan KuppusamyDepartment of Radiology and Medicine, Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA.
Rajan GognaChampalimaud Centre for the Unknown, Lisbon, Portugal. rajan.gogna@research.fchampalimaud.org.
Eduardo MorenoChampalimaud Centre for the Unknown, Lisbon, Portugal. eduardo.moreno@research.fchampalimaud.org.
Champalimaud Foundation · PTCreighton University · USAzabu University · JPUniversity of Arkansas for Medical Sciences · USDartmouth College · USHokkaido University Hospital · JPIndiana University Health · USIndiana University School of MedicineUniversity of Health Sciences and Pharmacy · USUniversity of Zurich · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans, the adaptive immune system uses the exchange of information between cells to detect and eliminate foreign or damaged cells; however, the removal of unwanted cells does not always require an adaptive immune system
Indexed as
Cell ProliferationAnimalsCalcium ChannelsCell Line, TumorCell Transformation, NeoplasticDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesHumansMaleNeoplasm MetastasisNeoplasmsProtein IsoformsCACFD1 protein, humanCalcium ChannelsDrosophila Proteinsfwe protein, DrosophilaProtein Isoforms
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.