Evidence map›Paper›PMID 31341231›Full record

ArticleScientific reports2019

Multimodal structural disease progression of retinitis pigmentosa according to mode of inheritance.

Ruben Jauregui, Vitor K L Takahashi, Karen Sophia Park, Xuan Cui, Julia T Takiuti, Jose Ronaldo Lima de Carvalho, Stephen H Tsang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Atypical retinitis pigmentosa associated withAmerican journal of ophthalmology case reports · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
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  11. Long-term natural history of ellipsoid zone width inThe British journal of ophthalmology · 2025
    Article
  12. Article
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  14. Article
  15. Article
  16. Observational
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ruben JaureguiDepartment of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA.
Vitor K L TakahashiDepartment of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA.
Karen Sophia ParkDepartment of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA.
Xuan CuiDepartment of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA.
Julia T TakiutiDepartment of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA.
Jose Ronaldo Lima de CarvalhoDepartment of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA.
Stephen H TsangDepartment of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA. sht2@cumc.columbia.edu.
NewYork–Presbyterian Hospital · USCornell University · USHospital das Clínicas da Universidade Federal de Pernambuco · BRUniversidade Federal de São Paulo · BR

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3M
Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
Toward mechanism- and gene-based therapies for retinal degenerationR01EY018213 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen H Tsang · 2008 to 2026
$6.6M
Gene Silencing and Gene Editing in PhototransductionR01EY024698 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen H Tsang · 2015 to 2026
$4.7M
Mechanistic Studies on Regenerative Medicine Approaches to Childhood BlindnessR01EY026682 · NEI · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G, MAHAJAN, VINIT B · 2016 to 2019
$1.6M
Evaluating GWAS AMD Candidate Loci by Gene Editing in Human iPS CellsR21AG050437 · NIA · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G, MAHAJAN, VINIT B · 2015 to 2016
$431k
NCI NIH HHS P30 CA013696NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY018213NEI NIH HHS R01 EY024698NEI NIH HHS R01 EY026682NIA NIH HHS R21 AG050437
6 · The paper itself

Abstract

We analyze disease progression in retinitis pigmentosa (RP) according to mode of inheritance by quantifying the progressive decrease of the ellipsoid zone (EZ) line width on spectral domain optical coherence tomography (SD-OCT) and of the dimensions of the hyperautofluorescent ring on short-wave fundus autofluorescence (SW-FAF). In this retrospective study of 96 patients, average follow-up time was 3.2 ± 1.9 years. EZ line width declined at a rate of -123 ± 8 µm per year, while the horizontal diameter and ring area declined at rates of -131 ± 9 µm and -0.5 ± 0.05 mm

Indexed as

Genes, DominantGenes, X-LinkedAdultAgedDisease ProgressionFemaleHumansMaleMiddle AgedRetinitis PigmentosaTomography, Optical Coherence

Identifiers

PMID31341231
PMCPMC6656765
OpenAlexW2964120491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.